Vegetable hierarchical structures as template for bone regeneration: New bio-ceramization process for the development of a bone scaffold applied to an experimental sheep model.
Animals
Bandages
Biocompatible Materials
/ chemistry
Bone Regeneration
Bone and Bones
/ metabolism
Cell Culture Techniques
Collagen
/ chemistry
Humans
Mechanical Phenomena
Osseointegration
Porosity
Sheep
Surface Properties
Tissue Engineering
Tissue Scaffolds
/ chemistry
Vegetables
/ chemistry
Wood
/ chemistry
Wound Healing
/ drug effects
bio-ceramization
bone regeneration
hierarchical structure
long bone defect
scaffold
Journal
Journal of biomedical materials research. Part B, Applied biomaterials
ISSN: 1552-4981
Titre abrégé: J Biomed Mater Res B Appl Biomater
Pays: United States
ID NLM: 101234238
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
12
09
2018
revised:
18
04
2019
accepted:
25
04
2019
pubmed:
17
5
2019
medline:
8
9
2021
entrez:
17
5
2019
Statut:
ppublish
Résumé
Long bone defects still represent a major clinical challenge in orthopedics, with the inherent loss of function considerably impairing the quality of life of the affected patients. Thus, the purpose of this study was to assess the safety and potential of bone regeneration offered by a load-bearing scaffold characterized by unique hierarchical architecture and high strength, with active surface facilitating new bone penetration and osseointegration in critical size bone defects. The results of this study showed the potential of bio-ceramization processes applied to vegetable hierarchical structures for the production of new wood-derived bone scaffolds, further improved by surface functionalization, with good biological and mechanical properties leading to successful treatment of critical size bone defects in the sheep model. Future studies are needed to evaluate if these scaffolds prototypes, as either biomaterial alone or in combination with augmentation strategies, may represent an optimal solution to enhance bone regeneration in humans.
Substances chimiques
Biocompatible Materials
0
Collagen
9007-34-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
600-611Informations de copyright
© 2019 Wiley Periodicals, Inc.
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