Childhood adversity and parenting behavior: the role of oxytocin receptor gene polymorphisms.
Childhood adversity
Gene–environment interaction
Mother–child interaction
Oxytocin receptor gene
Parenting
Journal
Journal of neural transmission (Vienna, Austria : 1996)
ISSN: 1435-1463
Titre abrégé: J Neural Transm (Vienna)
Pays: Austria
ID NLM: 9702341
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
08
11
2018
accepted:
05
05
2019
pubmed:
18
5
2019
medline:
28
7
2020
entrez:
18
5
2019
Statut:
ppublish
Résumé
Previous research revealed experiences of childhood adversity (CA) to be related to less favorable parenting behavior. It can further be expected that maternal oxytocin receptor (OXTR) genes may influence parenting behavior and moderate relationships between CA and parenting behavior. Moreover, associations between the OXTR gene and plasma oxytocin (OT) have been discussed. The present study investigated main effects of the OXTR gene on parenting behavior and plasma OT of mothers, and moderating effects of the OXTR gene on the relationship between mothers' experiences of CA and parenting behavior. We relied on a sample of 193 mothers and their on average 8-year-old children. Maternal experiences of CA were assessed using a standardized interview. A questionnaire for the assessment of child abuse potential and observations of mother-child interaction were used as indicators of parenting behavior. For mothers, we analyzed three polymorphisms (rs53576, rs1042778, rs2254298) of the OXTR gene and plasma OT. Only the rs53576 was associated with mothers' parenting behavior, specifically with maternal sensitivity. The rs2254298 significantly moderated relations between mothers' experiences of CA and parenting behavior. Significant relations could be found only for mothers who were homozygous for the G allele. The G allele of the rs2254298 was further related to increased plasma OT levels. Our findings underline the importance of considering genetic variation when investigating consequences of CA and developing intervention programs that are adapted to an individual's needs.
Identifiants
pubmed: 31098723
doi: 10.1007/s00702-019-02009-9
pii: 10.1007/s00702-019-02009-9
doi:
Substances chimiques
OXTR protein, human
0
Receptors, Oxytocin
0
Oxytocin
50-56-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
777-787Références
Psychol Bull. 2000 Nov;126(6):806-828
pubmed: 11107877
Child Abuse Negl. 2001 Sep;25(9):1219-40
pubmed: 11700694
Endocr Regul. 2005 Sep;39(3):97-105
pubmed: 16468232
Eur J Hum Genet. 2008 Oct;16(10):1164-72
pubmed: 18523454
Soc Cogn Affect Neurosci. 2008 Jun;3(2):128-34
pubmed: 19015103
Methods Mol Biol. 2009;578:307-43
pubmed: 19768603
Psychol Bull. 2009 Nov;135(6):885-908
pubmed: 19883141
Genet Epidemiol. 2010 Apr;34(3):266-74
pubmed: 20013941
Am J Psychiatry. 2010 May;167(5):509-27
pubmed: 20231323
Child Dev. 2010 Jan-Feb;81(1):41-79
pubmed: 20331654
Z Kinder Jugendpsychiatr Psychother. 2011 Jul;39(4):243-52
pubmed: 21667449
Nat Rev Neurosci. 2011 Aug 19;12(9):524-38
pubmed: 21852800
Am J Psychiatry. 2011 Oct;168(10):1041-9
pubmed: 21890791
Biol Psychiatry. 2012 Aug 1;72(3):175-81
pubmed: 22336563
BMC Med. 2012 Apr 17;10:38
pubmed: 22510359
Trauma Violence Abuse. 2012 Jul;13(3):135-52
pubmed: 22673145
Curr Opin Neurobiol. 2013 Feb;23(1):11-6
pubmed: 23040540
Neuropsychopharmacology. 2013 Jun;38(7):1154-62
pubmed: 23325323
Psychiatr Genet. 2014 Apr;24(2):45-51
pubmed: 23921259
Front Behav Neurosci. 2014 Jan 03;8:21
pubmed: 24550797
Emotion. 2014 Jun;14(3):562-72
pubmed: 24660771
Soc Neurosci. 2014;9(5):536-47
pubmed: 24968101
Psychoneuroendocrinology. 2014 Nov;49:161-70
pubmed: 25086828
Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12258-63
pubmed: 25092315
J Fam Psychol. 2015 Feb;29(1):91-9
pubmed: 25419912
Child Abuse Negl. 2015 Oct;48:179-89
pubmed: 26140735
Neuroscience. 2017 Feb 7;342:120-139
pubmed: 26386294
Biol Psychiatry. 2016 Feb 1;79(3):174-84
pubmed: 26392129
Front Neurosci. 2016 Jan 28;9:510
pubmed: 26858594
Biol Psychiatry. 2016 Apr 15;79(8):631-2
pubmed: 26997118
Dev Psychopathol. 2017 Aug;29(3):791-803
pubmed: 27292275
Behav Brain Res. 2017 May 15;325(Pt B):156-162
pubmed: 27343933
Front Hum Neurosci. 2016 Jul 19;10:358
pubmed: 27486392
Eur Eat Disord Rev. 2017 Jan;25(1):19-25
pubmed: 27862641
Neurosci Biobehav Rev. 2017 Feb;73:293-308
pubmed: 28027955
Front Neurosci. 2017 Apr 21;11:221
pubmed: 28484366
Psychiatry Clin Neurosci. 2017 Oct;71(10):690-705
pubmed: 28573830
Psychoneuroendocrinology. 2017 Nov;85:28-34
pubmed: 28800490
Curr Opin Psychol. 2017 Jun;15:13-18
pubmed: 28813252
PLoS One. 2018 Jun 18;13(6):e0199384
pubmed: 29912955
Psychoneuroendocrinology. 2019 Apr;102:172-181
pubmed: 30572177
J Child Psychol Psychiatry. 1994 Nov;35(8):1419-35
pubmed: 7868637
Psychol Bull. 1993 Nov;114(3):413-34
pubmed: 8272464
J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57
pubmed: 9881538