Synthetic developmental biology: build and control multicellular systems.
Journal
Current opinion in chemical biology
ISSN: 1879-0402
Titre abrégé: Curr Opin Chem Biol
Pays: England
ID NLM: 9811312
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
08
03
2019
revised:
03
04
2019
accepted:
09
04
2019
pubmed:
19
5
2019
medline:
3
4
2020
entrez:
19
5
2019
Statut:
ppublish
Résumé
Synthetic biology offers a bottom-up engineering approach that intends to understand complex systems via design-build-test cycles. Embryonic development comprises complex processes that originate at the level of gene regulatory networks in a cell and emerge into collective cellular behaviors with multicellular forms and functions. Here, we review synthetic biology approaches to development that involve building de novo developmental trajectories or engineering control in stem cell-derived multicellular systems. The field of synthetic developmental biology is rapidly growing with the help of recent advances in artificial gene circuits, self-organizing organoids, and controllable tissue microenvironments. The outcome will be a blueprint to decode principles of morphogenesis and to create programmable organoids with novel designs or improved functions.
Identifiants
pubmed: 31102790
pii: S1367-5931(19)30046-8
doi: 10.1016/j.cbpa.2019.04.006
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
9-15Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.