Subcritical Fluid Chromatography at Sub-Ambient Temperatures for the Chiral Resolution of Ketamine Metabolites with Rapid-Onset Antidepressant Effects.
Amylose
/ chemistry
Antidepressive Agents
/ isolation & purification
Carbon Dioxide
/ chemistry
Cellulose
/ chemistry
Chromatography, High Pressure Liquid
/ methods
Chromatography, Supercritical Fluid
/ methods
Ketamine
/ isolation & purification
Molecular Docking Simulation
Polysaccharides
/ chemistry
Reproducibility of Results
Stereoisomerism
Surface Properties
Temperature
chiral resolution
chiral stationary phase
coated
depression
immobilized
ketamine
metabolites
sub-ambient temperature
subcritical fluid chromatography
supercritical CO2
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
19 May 2019
19 May 2019
Historique:
received:
30
04
2019
revised:
13
05
2019
accepted:
17
05
2019
entrez:
22
5
2019
pubmed:
22
5
2019
medline:
28
11
2019
Statut:
epublish
Résumé
Chiral metabolites of ketamine exerting rapid-onset yet sustained antidepressant effects may be marketed directly in the future, but require chemo- and enantio-selective chromatographic methods for quality assurance and control. The chromatographic behavior of
Identifiants
pubmed: 31109124
pii: molecules24101927
doi: 10.3390/molecules24101927
pmc: PMC6572699
pii:
doi:
Substances chimiques
Antidepressive Agents
0
Polysaccharides
0
Carbon Dioxide
142M471B3J
Ketamine
690G0D6V8H
Cellulose
9004-34-6
Amylose
9005-82-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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