Two DevBCA-like ABC transporters are involved in the multidrug resistance of the cyanobacterium Anabaena sp. PCC 7120.
ABC transporter
Anabaena sp. PCC 7120
DevB homolog
cyanobacteria
multidrug resistance
tripartite efflux pump
Journal
FEBS letters
ISSN: 1873-3468
Titre abrégé: FEBS Lett
Pays: England
ID NLM: 0155157
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
04
04
2019
revised:
07
05
2019
accepted:
14
05
2019
pubmed:
23
5
2019
medline:
17
6
2020
entrez:
23
5
2019
Statut:
ppublish
Résumé
The filamentous heterocyst-forming cyanobacterium Anabaena sp. PCC 7120 is an important model organism for studying cell differentiation, nitrogen fixation, and photosynthesis. This cyanobacterium possesses a high number of membrane transporters. Not much is known about the roles of the membrane transporters, especially the ATP-binding cassette (ABC) transporters, in the multidrug resistance of this cyanobacterium. In the present work, we performed a mutational analysis of the genes alr4280/alr4281/alr4282 and alr3647/alr3648/alr3649 that code for the components of putative ABC exporters and are homologous to the DevBCA heterocyst-specific glycolipid exporter. We show that these genes are essential for resistance to different drugs and are not essential for heterocyst development.
Identifiants
pubmed: 31116406
doi: 10.1002/1873-3468.13450
doi:
Substances chimiques
ATP-Binding Cassette Transporters
0
Anti-Bacterial Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1818-1826Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : GRK 1708
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB 766
Pays : International
Informations de copyright
© 2019 Federation of European Biochemical Societies.