Phosphodiesterase 10A levels are related to striatal function in schizophrenia: a combined positron emission tomography and functional magnetic resonance imaging study.
Adolescent
Adult
Cognitive Dysfunction
/ etiology
Electroencephalography
Evoked Potentials, Auditory
/ physiology
Executive Function
/ physiology
Female
Humans
Magnetic Resonance Imaging
Male
Memory, Episodic
Middle Aged
Multimodal Imaging
Phosphoric Diester Hydrolases
Positron-Emission Tomography
Putamen
/ diagnostic imaging
Schizophrenia
/ complications
Substantia Nigra
/ diagnostic imaging
Young Adult
Dopamine
Phosphodiesterase 10A
Resting state
Schizophrenia
Striatum
Journal
European archives of psychiatry and clinical neuroscience
ISSN: 1433-8491
Titre abrégé: Eur Arch Psychiatry Clin Neurosci
Pays: Germany
ID NLM: 9103030
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
03
01
2019
accepted:
15
05
2019
pubmed:
24
5
2019
medline:
1
12
2020
entrez:
24
5
2019
Statut:
ppublish
Résumé
Pharmacological inhibition of phosphodiesterase 10A (PDE10A) is being investigated as a treatment option in schizophrenia. PDE10A acts postsynaptically on striatal dopamine signaling by regulating neuronal excitability through its inhibition of cyclic adenosine monophosphate (cAMP), and we recently found it to be reduced in schizophrenia compared to controls. Here, this finding of reduced PDE10A in schizophrenia was followed up in the same sample to investigate the effect of reduced striatal PDE10A on the neural and behavioral function of striatal and downstream basal ganglia regions. A positron emission tomography (PET) scan with the PDE10A ligand [
Identifiants
pubmed: 31119377
doi: 10.1007/s00406-019-01021-0
pii: 10.1007/s00406-019-01021-0
pmc: PMC7210243
doi:
Substances chimiques
PDE10A protein, human
EC 3.1.4.-
Phosphoric Diester Hydrolases
EC 3.1.4.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
451-459Subventions
Organisme : Vetenskapsrådet
ID : 2016-02362
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