Activation of liver X receptor up-regulates the expression of the NKG2D ligands MICA and MICB in multiple myeloma through different molecular mechanisms.
Adaptive Immunity
/ physiology
Apoptosis
/ genetics
Cell Line
Cells, Cultured
Chromatography, Thin Layer
Flow Cytometry
Gene Expression Regulation, Neoplastic
Histocompatibility Antigens Class I
/ genetics
Humans
Immunity, Innate
/ physiology
Inflammation
/ metabolism
Killer Cells, Natural
/ metabolism
Liver X Receptors
/ genetics
Microscopy, Confocal
Multiple Myeloma
/ genetics
Promoter Regions, Genetic
/ genetics
LXR
cholesterol
natural killer
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
pubmed:
28
5
2019
medline:
2
6
2020
entrez:
25
5
2019
Statut:
ppublish
Résumé
NK cells have an important role in immunosurveillance of multiple myeloma (MM) progression, and their activity is enhanced by combination therapies able to regulate the expression of specific activating ligands. Liver X receptors (LXRs) are nuclear receptors and important regulators of intracellular cholesterol and lipid homeostasis. Moreover, they have regulatory roles in both cancer and immune response. Indeed, they can regulate inflammation and innate and acquired immunity. Furthermore, LXR activation directly acts in cancer cells (
Identifiants
pubmed: 31125275
doi: 10.1096/fj.201900319R
doi:
Substances chimiques
Histocompatibility Antigens Class I
0
Liver X Receptors
0
MHC class I-related chain A
0
MICB antigen
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM