Histone deacetylase 6 inhibitor tubastatin A attenuates angiotensin II-induced hypertension by preventing cystathionine γ-lyase protein degradation.
Angiotensin II
/ pharmacology
Animals
Aorta
/ cytology
Cystathionine gamma-Lyase
/ metabolism
Endothelial Cells
/ metabolism
HEK293 Cells
Histone Deacetylase 6
/ antagonists & inhibitors
Histone Deacetylase Inhibitors
/ pharmacology
Humans
Hydrogen Sulfide
/ metabolism
Hydroxamic Acids
/ pharmacology
Hypertension
/ chemically induced
Indoles
/ pharmacology
Male
Mice, Inbred C57BL
Proteolysis
/ drug effects
Angiotensin II
Angiotensin II (PubChem CID: 172198)
Cystathionine γ-lyase
Histone deacetylase 6
Hydrogen sulfide
Hypertension
Tubastatin A
Tubastatin A (PubChem CID: 49850262)
Journal
Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
11
02
2019
revised:
20
05
2019
accepted:
20
05
2019
pubmed:
28
5
2019
medline:
22
5
2020
entrez:
25
5
2019
Statut:
ppublish
Résumé
Cystathionine γ-lyase (CSEγ) is a hydrogen sulfide (H
Identifiants
pubmed: 31125601
pii: S1043-6618(19)30248-8
doi: 10.1016/j.phrs.2019.104281
pii:
doi:
Substances chimiques
Histone Deacetylase Inhibitors
0
Hydroxamic Acids
0
Indoles
0
Angiotensin II
11128-99-7
tubastatin A
2XTSOX1NF8
Hdac6 protein, mouse
EC 3.5.1.98
Histone Deacetylase 6
EC 3.5.1.98
Cystathionine gamma-Lyase
EC 4.4.1.1
Hydrogen Sulfide
YY9FVM7NSN
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104281Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.