Sputum biomarkers during aspirin desensitization in nonsteroidal anti-inflammatory drugs exacerbated respiratory disease.
Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal
/ administration & dosage
Aspirin
/ administration & dosage
Asthma
/ chemically induced
Biomarkers
/ blood
Carrier Proteins
/ metabolism
Cell Adhesion Molecules
/ blood
Desensitization, Immunologic
/ methods
Eicosanoids
/ metabolism
Eosinophils
/ drug effects
Female
Humans
Lipoproteins
/ metabolism
Male
Middle Aged
Nasal Lavage Fluid
/ immunology
Prospective Studies
Respiration Disorders
/ chemically induced
Sputum
/ metabolism
Symptom Flare Up
Trans-Activators
/ metabolism
Visual Analog Scale
Aspirin desensitization
Eicosanoids
Induced sputum
Nasal lavage
Nonsteroidal anti-inflammatory drugs exacerbated respiratory disease
Periostin
Journal
Respiratory medicine
ISSN: 1532-3064
Titre abrégé: Respir Med
Pays: England
ID NLM: 8908438
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
27
01
2019
revised:
10
04
2019
accepted:
29
04
2019
entrez:
27
5
2019
pubmed:
28
5
2019
medline:
28
4
2020
Statut:
ppublish
Résumé
Aspirin desensitization (AD) is an effective and safe therapeutic option for patients with nonsteroidal anti-inflammatory drugs (NSAIDs)-exacerbated respiratory disease (N-ERD). The mechanisms driving its beneficial effects remain poorly understood. To investigate the effect of long-term AD on clinical, biochemical and radiological changes in N-ERD patients. The study group consisted of twenty-three individuals with N-ERD who underwent AD, followed by ingestion of 325 mg aspirin twice daily. Twenty patients completed the 52 weeks of AD. The following evaluations were conducted at baseline and in the 52nd week of AD: (i) clinical: asthma exacerbations, Asthma Control Test (ACT), Visual Analogue Scale (VAS) for the assessment of nasal symptoms; (ii) blood and induced sputum supernatant (ISS) periostin, (iii) phenotypes based on induced sputum (IS) cells, (iiii) ISS and nasal lavage (NL) concentration of prostaglandin D A significant improvement was observed in ACT (P = 0.02) and VAS score (P = 0.008) in the 52nd week of AD. ISS periostin and IS eosinophil count decreased significantly in the 52nd week of AD (P = 0.04 and P = 0.01, respectively). ISS and NL eicosanoid concentrations did not change following long-term AD. and Clinical Relevance: AD is associated with a decrease in sputum periostin biosynthesis, which may prevent the recruitment of eosinophils into respiratory tissue and be one of explanation of the clinical benefits of AD. Long-term aspirin administration does not lead to an imbalance between pro- and anti-inflammatory ISS eicosanoids.
Sections du résumé
BACKGROUND
Aspirin desensitization (AD) is an effective and safe therapeutic option for patients with nonsteroidal anti-inflammatory drugs (NSAIDs)-exacerbated respiratory disease (N-ERD). The mechanisms driving its beneficial effects remain poorly understood.
OBJECTIVE
To investigate the effect of long-term AD on clinical, biochemical and radiological changes in N-ERD patients.
METHODS
The study group consisted of twenty-three individuals with N-ERD who underwent AD, followed by ingestion of 325 mg aspirin twice daily. Twenty patients completed the 52 weeks of AD. The following evaluations were conducted at baseline and in the 52nd week of AD: (i) clinical: asthma exacerbations, Asthma Control Test (ACT), Visual Analogue Scale (VAS) for the assessment of nasal symptoms; (ii) blood and induced sputum supernatant (ISS) periostin, (iii) phenotypes based on induced sputum (IS) cells, (iiii) ISS and nasal lavage (NL) concentration of prostaglandin D
RESULTS
A significant improvement was observed in ACT (P = 0.02) and VAS score (P = 0.008) in the 52nd week of AD. ISS periostin and IS eosinophil count decreased significantly in the 52nd week of AD (P = 0.04 and P = 0.01, respectively). ISS and NL eicosanoid concentrations did not change following long-term AD.
CONCLUSION
and Clinical Relevance: AD is associated with a decrease in sputum periostin biosynthesis, which may prevent the recruitment of eosinophils into respiratory tissue and be one of explanation of the clinical benefits of AD. Long-term aspirin administration does not lead to an imbalance between pro- and anti-inflammatory ISS eicosanoids.
Identifiants
pubmed: 31128610
pii: S0954-6111(19)30149-0
doi: 10.1016/j.rmed.2019.04.021
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Biomarkers
0
Carrier Proteins
0
Cell Adhesion Molecules
0
Eicosanoids
0
Lipoproteins
0
POSTN protein, human
0
SEC14L2 protein, human
0
Trans-Activators
0
Aspirin
R16CO5Y76E
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
51-59Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.