Design of Oxytocin Analogs.
Clinical use
Duration of action
OTR agonists
OTR antagonists
Oxytocin (OT)
Oxytocin receptor (OTR)
Selectivity
Journal
Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
29
5
2019
pubmed:
28
5
2019
medline:
13
3
2020
Statut:
ppublish
Résumé
The neurohypophyseal hormone oxytocin (OT) and related modulators of the oxytocin receptor (OTR) have been the subject of intensive research for nearly seven decades. Despite having rather poor drug-like properties, OT is used as a treatment for labor induction, postpartum hemorrhage, and lactation support. The potential use of OT in the treatment of central nervous system (CNS)-related diseases has recently renewed interest in the pharmacology of OT. Oxytocin is one of the most extensively studied cyclic peptides and since the elucidation of its structure in 1953 thousands of peptidic OT analogs with antagonistic and agonistic properties have been synthesized and biologically evaluated. Among them are atosiban, a mixed oxytocin receptor (OTR)/vasopressin 1a receptor (V
Identifiants
pubmed: 31134574
doi: 10.1007/978-1-4939-9504-2_11
doi:
Substances chimiques
Antidiuretic Hormone Receptor Antagonists
0
Oligopeptides
0
Receptors, Oxytocin
0
atosiban
081D12SI0Z
Oxytocin
50-56-6
carbetocin
88TWF8015Y
barusiban
UX33I93GLS
Vasotocin
W6S6URY8OF
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM