Schistosoma mansoni venom allergen-like proteins: phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity.
Allergens
/ classification
Animals
Antigens, Helminth
/ classification
Blotting, Western
Cross Reactions
Dengue Vaccines
/ immunology
Electrophoresis, Gel, Two-Dimensional
Electrophoresis, Polyacrylamide Gel
Gene Expression Profiling
Helminth Proteins
/ classification
Immune Sera
/ immunology
Mass Spectrometry
Multigene Family
Phylogeny
Schistosoma mansoni
/ chemistry
Transcription, Genetic
Immunological cross reactivity
Schistosoma mansoni
Tissue localization
Venom allergen-like
Journal
International journal for parasitology
ISSN: 1879-0135
Titre abrégé: Int J Parasitol
Pays: England
ID NLM: 0314024
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
21
12
2018
revised:
25
03
2019
accepted:
28
03
2019
pubmed:
29
5
2019
medline:
29
4
2020
entrez:
29
5
2019
Statut:
ppublish
Résumé
Schistosoma mansoni venom allergen-like proteins (SmVALs) are part of a diverse protein superfamily partitioned into two groups (group 1 and group 2). Phylogenetic analyses of group 1 SmVALs revealed that members could be segregated into subclades (A-D); these subclades share similar gene expression patterns across the parasite lifecycle and immunological cross-reactivity. Furthermore, whole-mount in situ hybridization demonstrated that the phylogenetically, transcriptionally and immunologically-related SmVAL4, 10, 18 and 19 (subclade C) were all localized to the pre-acetabular glands of immature cercariae. Our results suggest that SmVAL group 1 phylogenetic relationships, stage-specific transcriptional profiles and tissue localization are predictive of immunological cross-reactivity.
Identifiants
pubmed: 31136745
pii: S0020-7519(19)30131-6
doi: 10.1016/j.ijpara.2019.03.003
pmc: PMC6598858
pii:
doi:
Substances chimiques
Allergens
0
Antigens, Helminth
0
Dengue Vaccines
0
Helminth Proteins
0
Immune Sera
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
593-599Subventions
Organisme : Wellcome Trust
ID : WT084273/Z/07/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
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