Extracellular cold inducible RNA-binding protein mediates binge alcohol-induced brain hypoactivity and impaired cognition in mice.
Amygdala
/ drug effects
Animals
Binge Drinking
/ complications
Brain
/ drug effects
Cognitive Dysfunction
/ drug therapy
Fluorodeoxyglucose F18
/ analysis
Hippocampus
/ drug effects
Male
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Positron-Emission Tomography
RNA-Binding Proteins
/ genetics
Spatial Memory
/ drug effects
Amygdala
CIRP
Fluorodeoxyglucose
Hippocampus
Spatial memory
microPET
Journal
Molecular medicine (Cambridge, Mass.)
ISSN: 1528-3658
Titre abrégé: Mol Med
Pays: England
ID NLM: 9501023
Informations de publication
Date de publication:
30 05 2019
30 05 2019
Historique:
received:
18
04
2019
accepted:
15
05
2019
entrez:
1
6
2019
pubmed:
31
5
2019
medline:
23
6
2020
Statut:
epublish
Résumé
Alcohol abuse affects the brain regions responsible for memory, coordination and emotional processing. Binge alcohol drinking has shown reductions in brain activity, but the molecular targets have not been completely elucidated. We hypothesized that brain cells respond to excessive alcohol by releasing a novel inflammatory mediator, called cold inducible RNA-binding protein (CIRP), which is critical for the decreased brain metabolic activity and impaired cognition. Male wild type (WT) mice and mice deficient in CIRP (CIRP Statistical Parametric Analysis (SPM) of CIRP released from brain cells could be responsible for regional brain metabolic hypoactivity leading to cognitive impairment under binge alcohol conditions.
Sections du résumé
BACKGROUND
Alcohol abuse affects the brain regions responsible for memory, coordination and emotional processing. Binge alcohol drinking has shown reductions in brain activity, but the molecular targets have not been completely elucidated. We hypothesized that brain cells respond to excessive alcohol by releasing a novel inflammatory mediator, called cold inducible RNA-binding protein (CIRP), which is critical for the decreased brain metabolic activity and impaired cognition.
METHODS
Male wild type (WT) mice and mice deficient in CIRP (CIRP
RESULTS
Statistical Parametric Analysis (SPM) of
CONCLUSION
CIRP released from brain cells could be responsible for regional brain metabolic hypoactivity leading to cognitive impairment under binge alcohol conditions.
Identifiants
pubmed: 31146675
doi: 10.1186/s10020-019-0092-3
pii: 10.1186/s10020-019-0092-3
pmc: PMC6543653
doi:
Substances chimiques
Cirbp protein, mouse
0
RNA-Binding Proteins
0
Fluorodeoxyglucose F18
0Z5B2CJX4D
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
24Subventions
Organisme : NIAAA NIH HHS
ID : R21AA021496
Pays : United States
Organisme : NIAAA NIH HHS
ID : R21AA025574
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : 5P01AI102852
Pays : International
Organisme : National Institute of Allergy and Infectious Diseases
ID : 5P01AI073693
Pays : International
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