The epidemiology of amyloidosis in Queensland, Australia.
amyloid
amyloidosis
epidemiology
Journal
British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
21
01
2019
accepted:
11
04
2019
pubmed:
31
5
2019
medline:
2
6
2020
entrez:
1
6
2019
Statut:
ppublish
Résumé
Published studies on the epidemiology of amyloidosis have relied on death certificate data for case ascertainment. We estimated the incidence and mortality burden of amyloidosis among residents of the Australian state, Queensland, aged ≥20 years for the years 1999-2013 based on case ascertainment from histopathology reports. Information systems for participating laboratories were scrutinised to identify histopathology reports that documented a diagnosis of amyloidosis. Case mortality status was determined via linkage to the National Death Index. A total of 447 cases of amyloidosis were identified, with a median age at diagnosis of 66 years. A plasma cell dyscrasia was identified in 72% of patients who had paraprotein studies performed. The estimated incidence for Queenslanders aged ≥20 years was 12·1 cases per million person years. The median survival was 2·45 years. Age at diagnosis, presence of a paraprotein, earlier year of diagnosis, and inner regional location of residence (compared with residence in a major city) were independently associated with reduced survival. Our data confirms previously reported incidence data for amyloidosis of approximately 10 cases per million patient years and indicates that survival for Queensland patients with amyloidosis is improving, though it remains poor for the elderly and patients with AL amyloidosis.
Types de publication
Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
829-836Informations de copyright
© 2019 British Society for Haematology and John Wiley & Sons Ltd.
Références
Australian Bureau of Statistics (2014) Population estimates by remoteness area, 2003 to 2013. Available at: http://www.abs.gov.au/AUSSTATS/abs@.nsf/DetailsPage/3218.02012-13 (Accessed March 18, 2019).
Bemporad, F. & Chiti, F. (2012) Protein misfolded oligomers: experimental approaches, mechanism of formation, and structure-toxicity relationships. Chemistry and Biology, 19, 315-327.
D’Souza, A., Dispenzieri, A., Wirk, B., Zhang, M., Huang, J., Gertz, M., Kyle, R.A., Kumar, S., Comenzo, R.L., Gale, R.P., Lazarus, H.M., Savani, B.N., Cornell, R.F., Weiss, B.M., Vogl, D.T., Freytes, C.O., Scott, E.C., Landau, H.J., Moreb, J.S., Costa, L.J., Ramanathan, M., Callander, N.S., Kamble, R.T., Olsson, R.F., Ganguly, S., Nishihori, T., Kindwall-Keller, T.L., Wood, W.A., Mark, T.M. & Hari, P. (2015) Improved outcomes after autologous haematopoietic cell transplantation for light chain amyloidosis: a Center for International Blood and Marrow Transplant Research study. Journal of Clinical Oncology, 33, 3741-3749.
Hemminki, K., Li, X., Forsti, A., Sundquist, J. & Sundquist, K. (2012) Incidence and survival in non-hereditary amyloidosis in Sweden. BMC Public Health, 12, 974.
Kumar, S.K., Gertz, M.A., Lacy, M.Q., Dingli, D., Hayman, S.R., Baudi, F.K., Short-Detweiler, K., Zeldenrust, S.R., Leung, N., Greipp, P.R., Lust, J.A., Russell, S.J., Kyle, R.A., Rajkumar, S.V. & Dispenzieri, A. (2011) Recent improvements is survival in primary systemic amyloidosis and the importance of an early risk score. Mayo Clinic Proceedings, 86, 12-18.
Kumar, S.K., Hayman, S.R., Buadi, F.K., Roy, V., Lacy, M.Q., Gertz, M.A., Alfred, J., Laumann, K.M., Bergsagel, L.P., Dingli, D., Mikhael, J.R., Reeder, C.B., Stewart, A.K., Zeldenrust, S.R., Greipp, P.R., Lust, J.A., Fonseca, R., Russell, S.J., Rajkumar, S.V. & Dispenzieri, A. (2012) Lenalidomide, cyclophosphamide, and dexamethasone (CRd) for light-chain amyloidosis: long-term results from a phase 2 trial. Blood, 119, 4860-4867.
Kyle, R.A., Linos, A., Beard, C.M., Linke, R.P., Gertz, M.A., O’Fallon, M. & Kurland, L.T. (1992) Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989. Blood, 79, 1817-1822.
Kyle, R.A., Therneau, T.M., Rajkumar, S.V., Larson, D.R., Plevak, M.F., Offord, J.R., Dispenzieri, A., Katzmann, J.A. & Melton, L.J. III (2006) Prevalence of monoclonal gammopathy of undetermined significance. New England Journal of Medicine, 354, 1362-1369.
Mollee, P., Boros, S., Loo, D., Ruelcke, J.E., Lakis, V.A., Cao, K.L., Renaut, R. & Hill, M.M. (2016) Implementation and evaluation of amyloidosis subtyping by laser-capture microdissection and tandem mass spectrometry. Clinical Proteomics, 13, 30.
Muchtar, E., Gertz, M.A., Kumar, S.K., Lacy, M.Q., Dingli, D., Buadi, F.K., Grogan, M., Hayman, S.R., Kapoor, P., Leung, N., Fonder, A., Hobbs, M., Hwa, Y.L., Gonsalves, W., Warsame, R., Kourelis, T.V., Russell, S., Lust, J.A., Lin, Y., Go, R.S., Zeldenrust, S., Kyle, R.A., Rajkumar, S.V. & Dispenzieri, A. (2017) Improved outcomes for newly diagnosed AL amyloidosis between 2000 and 2014: cracking the glass ceiling of early death. Blood, 129, 2111-2119.
Palladini, G., Russo, P., Bosoni, T., Verga, L., Sarais, G., Lavatelli, F., Nuvulone, M., Obici, L., Casarini, S., Donadei, S., Albertini, R., Righetti, G., Marini, M., Graziani, M.S., D’Eril, G.V.M., Moratti, R. & Merlini, G. (2009) Identification of amyloidogenic light chains requires the combination of serum free light chain assay with immunofixation of serum and urine. Clinical Chemistry, 55, 499-504.
Palladini, G., Sachchithanantham, S., Milani, P., Gillmore, J., Foli, A., Lachmann, H., Basset, M., Hawkins, P., Merlini, G. & Wechalekar, A.D. (2015) A European collaborative study of cyclophosphamide, bortezomib, and dexamethasone in upfront treatment of systemic AL amyloidosis. Blood, 126, 612-615.
Parmar, S., Kongtim, P., Champlin, R., Dinh, Y., Elgharably, Y., Wang, M., Bashir, Q., Shah, J.J., Shah, N., Popat, U., Giralt, S.A., Orlowski, R.Z. & Qazilbash, M.H. (2014) Auto-SCT improves survival in systmic light chain amyloidosis: a retropective analysis with 14-year follow-up. Bone Marrow Transplantation, 49, 1036-1041.
Pinney, J.H., Smith, C.J., Taube, J.B., Lachmann, H.J., Venner, C.P., Gibbs, S.D.J., Dungu, J., Banyperasad, S.M., Wechalekar, A.D., Whelan, C.J., Hawkins, P.N. & Gillmore, J.D. (2013a) Systemic amyloidosis in England: and epidemiological study. British Journal of Haematology, 161, 525-532.
Pinney, J.H., Whelan, C.J., Petrie, A., Dungu, J., Banypersad, S.M., Sattianayagam, P., Wechalekar, A., Gibbs, S.D.J., Venner, C.P., Wassef, N., McCarthy, C.A., Gilbertson, J.A., Rowczenio, D., Hawkins, P.N., Gillmore, J.D. & Lachmann, H.J. (2013b) Senile systemic amyloidosis: clinical features at presentation an outcome. Journal of the American Heart Association, 2, e000098.
Rapezzi, C., Merlini, G., Quarta, C.C., Riva, L., Longhi, S., Leone, O., Salvi, F., Ciliberti, P., Pastorelli, F., Biagini, E., Coccolo, F., Cooke, R.M.T., Bacchi-Reggiani, L., Sangiori, D., Ferlini, A., Cavo, M., Zamagni, E., Fonte, M.L., Palladini, G., Salinaro, F., Musca, F., Obici, L., Branzi, A. & Perlini, S. (2009) Systemic cardiac amyloidoses: disease profiles and clinical courses of the 3 main types. Circulation, 120, 1203-1212.
Sachchithanantham, S., Offer, M., Venner, C., Mahmood, S.A., Foard, D., Rannigan, L., Lane, T., Gilmore, J.D., Lachmann, H.J., Hawkins, P.N. & Wechalekar, A.D. (2015) Clinical profile and treatment outcome of older (>75 years) patients with systemic AL amyloidosis. Haematologica, 100, 1469-1476.
Simms, R.W., Prout, M.N. & Cohen, A.S. (1994) The epidemiology of AL and AA amyloidosis. Bailliere’s Clincal Rheumatology, 8, 627-634.
Sipe, J.D., Benson, M.D., Buxbaum, J.N., Ikeda, S., Merlini, G., Saraiva, M.J.M. & Westermark, P. (2016) Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 nomenclature guidelines. Amyloid, 23, 209-213.
US Census Bureau (1990) Table 2. Age: Minnesota. Available at: https://www.census.gov/prod/1/90dec/cph4/tables/cph4tb25/table-02.pdf (Accessed April 7, 2019).
US Census Bureau (2016) QuickFacts, Olmsted County, Minnesota. Available at: https://www.census.gov/quickfacts/fact/table/olmstedcountyminnesota/PST045216 (Accessed 7 April, 2019).