The molecular determinants of neurosteroid binding in the GABA(A) receptor.

Amino Acid Sequence Binding Sites Crystallography, X-Ray Glutamine / chemistry Humans Models, Molecular Molecular Dynamics Simulation Mutagenesis, Site-Directed Mutation Neurosteroids / chemistry Protein Conformation Protein Domains Receptors, GABA-A / chemistry Sequence Homology Tryptophan / chemistry
ELIC GABA receptor Mass spectrometry Mutation Neurosteroid Photoaffinity labeling

Journal

The Journal of steroid biochemistry and molecular biology
ISSN: 1879-1220
Titre abrégé: J Steroid Biochem Mol Biol
Pays: England
ID NLM: 9015483

Informations de publication

Date de publication:
09 2019
Historique:
received: 26 02 2019
revised: 11 05 2019
accepted: 26 05 2019
pubmed: 1 6 2019
medline: 22 1 2020
entrez: 1 6 2019
Statut: ppublish

Résumé

Neurosteroids positively modulate GABA-A receptor (GABA

Identifiants

DOI: 10.1016/j.jsbmb.2019.105383 PMID: 31150831 PMC: PMC6708749
pubmed: 31150831
pii: S0960-0760(19)30111-6
doi: 10.1016/j.jsbmb.2019.105383
pmc: PMC6708749
mid: NIHMS1532024
pii:
doi:

Substances chimiques

Neurosteroids 0
Receptors, GABA-A 0
Glutamine 0RH81L854J
Tryptophan 8DUH1N11BX

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

105383

Subventions

Organisme : NIGMS NIH HHS
ID : K08 GM126336
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM108580
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM108799
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM108539
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Références

Pharmacol Ther. 2007 Oct;116(1):35-57
pubmed: 17524487
Nature. 2014 Aug 21;512(7514):270-5
pubmed: 24909990
Annu Rev Biochem. 1993;62:483-514
pubmed: 8352595
Neuropharmacology. 2016 Sep;108:193-206
pubmed: 27114255
Neuropharmacology. 2009 Jan;56(1):149-54
pubmed: 18762201
Mol Pharmacol. 2008 Sep;74(3):614-27
pubmed: 18544665
Proteins. 2015 Jul;83(7):1297-306
pubmed: 25921217
Steroids. 2009 Jul;74(7):577-85
pubmed: 19103212
Mol Pharmacol. 2012 Sep;82(3):408-19
pubmed: 22648971
Anesthesiology. 2016 Mar;124(3):664-73
pubmed: 26756520
J Biol Chem. 2018 Feb 23;293(8):3013-3027
pubmed: 29301936
Nat Struct Mol Biol. 2017 Nov;24(11):986-992
pubmed: 28991263
Mol Pharmacol. 1996 Dec;50(6):1581-6
pubmed: 8967980
J Steroid Biochem Mol Biol. 2018 Sep;182:72-80
pubmed: 29705269
J Biol Chem. 2017 Jun 2;292(22):9294-9304
pubmed: 28396346
EMBO J. 2013 Mar 6;32(5):728-41
pubmed: 23403925
J Chem Inf Model. 2009 Feb;49(2):330-7
pubmed: 19434834
Structure. 2012 Aug 8;20(8):1293-9
pubmed: 22884106
Nat Rev Neurosci. 2005 Jul;6(7):565-75
pubmed: 15959466
J Chem Theory Comput. 2016 Jan 12;12(1):405-13
pubmed: 26631602
PLoS Biol. 2019 Mar 7;17(3):e3000157
pubmed: 30845142
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Feb;1864(2):128-136
pubmed: 30471426
J Biol Chem. 2018 Aug 31;293(35):13427-13439
pubmed: 29986886
Trends Pharmacol Sci. 2016 Jul;37(7):543-561
pubmed: 27156439
Anal Chem. 2015 Apr 21;87(8):4370-6
pubmed: 25799115
J Physiol. 2012 Nov 15;590(22):5739-47
pubmed: 22988137
Nat Struct Mol Biol. 2017 Nov;24(11):977-985
pubmed: 28967882
Front Mol Neurosci. 2016 Jun 16;9:44
pubmed: 27378845
J Comput Chem. 2010 Jan 30;31(2):455-61
pubmed: 19499576
Biophys J. 2015 Oct 20;109(8):1528-32
pubmed: 26488642
J Cheminform. 2011 Oct 07;3:33
pubmed: 21982300
Nature. 2006 Nov 23;444(7118):486-9
pubmed: 17108970
J Biol Chem. 2012 Nov 23;287(48):40224-31
pubmed: 23038269
Nat Commun. 2018 Sep 28;9(1):3972
pubmed: 30266951
Chem Rev. 2011 Aug 10;111(8):4405-17
pubmed: 21466226

Auteurs

Yusuke Sugasawa (Y)

Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO 63110, USA. Electronic address: sugasaway@wustl.edu.

John R Bracamontes (JR)

Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO 63110, USA. Electronic address: jbracamontes@wustl.edu.

Kathiresan Krishnan (K)

Department of Developmental Biology, Washington University in St. Louis, St. Louis, MO 63110, USA. Electronic address: krishnan@wustl.edu.

Douglas F Covey (DF)

Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Developmental Biology, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Psychiatry, Washington University in St. Louis, St. Louis, MO 63110, USA; Taylor Family Institute for Innovative Psychiatric Research, Washington University in St. Louis, St. Louis, MO 63110, USA. Electronic address: dcovey@wustl.edu.

David E Reichert (DE)

Department of Radiology, Washington University in St. Louis, St. Louis, MO 63110, USA; Taylor Family Institute for Innovative Psychiatric Research, Washington University in St. Louis, St. Louis, MO 63110, USA. Electronic address: reichertd@wustl.edu.

Gustav Akk (G)

Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO 63110, USA; Taylor Family Institute for Innovative Psychiatric Research, Washington University in St. Louis, St. Louis, MO 63110, USA. Electronic address: akk@wustl.edu.

Qiang Chen (Q)

Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA. Electronic address: qic8@pitt.edu.

Pei Tang (P)

Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA. Electronic address: ptang@pitt.edu.

Alex S Evers (AS)

Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Developmental Biology, Washington University in St. Louis, St. Louis, MO 63110, USA; Taylor Family Institute for Innovative Psychiatric Research, Washington University in St. Louis, St. Louis, MO 63110, USA. Electronic address: eversa@wustl.edu.

Wayland W L Cheng (WWL)

Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO 63110, USA. Electronic address: wayland.cheng@wustl.edu.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › The molecular determinants of neurosteroid...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › The molecular determinants of neurosteroid...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › The molecular determinants of neurosteroid...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés neutres › Glutamine › The molecular determinants of neurosteroid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The molecular determinants of neurosteroid...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › The molecular determinants of neurosteroid...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › The molecular determinants of neurosteroid...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Ingénierie des protéines › Mutagenèse dirigée › The molecular determinants of neurosteroid...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › The molecular determinants of neurosteroid...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Neurostéroïdes › The molecular determinants of neurosteroid...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › The molecular determinants of neurosteroid...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Domaines protéiques › The molecular determinants of neurosteroid...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › Récepteurs GABA-A › The molecular determinants of neurosteroid...
questionsmedicales.fr › Phénomènes génétiques › Similitude de séquences › The molecular determinants of neurosteroid...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Tryptophane › The molecular determinants of neurosteroid...