Automated evaluation of hippocampal subfields volumes in mesial temporal lobe epilepsy and its relationship to the surgical outcome.
Automated segmentation
Freesurfer
Hippocampal sclerosis
Hippocampal subfields
Temporal lobe epilepsy
Journal
Epilepsy research
ISSN: 1872-6844
Titre abrégé: Epilepsy Res
Pays: Netherlands
ID NLM: 8703089
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
12
03
2019
revised:
12
05
2019
accepted:
23
05
2019
pubmed:
4
6
2019
medline:
14
7
2020
entrez:
2
6
2019
Statut:
ppublish
Résumé
The International League Against Epilepsy (ILAE) classification system for hippocampal sclerosis (HS) is based on location and extent of hippocampal neuron loss. Specific subgroups have a better surgical prognosis. Automated hippocampal subfields segmentation and volume measure could be obtained from high field MRI and used to pre-operatively classify the patients in ILAE subgroups to define best candidates for surgery. This prospective study included 86 MTLE patients, candidates to surgical treatment and ten healthy volunteers. Volumetric analysis of the hippocampal sublayers was performed through the Freesurfer software, using 3 Teslas volumetric T1 weighted MRI. We correlated the hippocampal subfields measures with the seizure control after one year from surgery. Volume loss in Cornu Amonis (CA) 1 and 4 were related to better surgical outcome after one year. Atrophy in CA 2 and CA 3 did not improve the prognosis. These results are in agreement with the ILAE classification of hippocampal subfields sclerosis.
Identifiants
pubmed: 31153103
pii: S0920-1211(19)30143-3
doi: 10.1016/j.eplepsyres.2019.05.011
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
152-156Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.