The Genetics of Psoriasis and Psoriatic Arthritis.

Alleles Arthritis, Psoriatic / genetics Genetic Predisposition to Disease Genome-Wide Association Study Genotype HLA-C Antigens / genetics Humans Polymorphism, Single Nucleotide Psoriasis / genetics
GENETICS GRAPPA PSORIASIS PSORIATIC ARTHRITIS RESEARCH

Journal

The Journal of rheumatology. Supplement
ISSN: 0380-0903
Titre abrégé: J Rheumatol Suppl
Pays: Canada
ID NLM: 7806058

Informations de publication

Date de publication:
Jun 2019
Historique:
entrez: 3 6 2019
pubmed: 4 6 2019
medline: 19 12 2019
Statut: ppublish

Résumé

Psoriatic arthritis (PsA) is an inflammatory arthritis that manifests in 20-30% of patients diagnosed with psoriasis. Epidemiologic studies suggest a substantial genetic contribution to PsA. There is a strong need for genome-wide association studies on patients with PsA, including PsA-weighted or specific variants, and a need for a better understanding of the relevance of HLA alleles in disease expression. Interferon signaling and the nuclear factor-κB cascade are involved in PsA, and there are genetic differences between purely cutaneous psoriasis (PsC) and PsA. Psoriasis susceptibility genes for which putative functional coding variants in

Identifiants

DOI: 10.3899/jrheum.190119 PMID: 31154404
pubmed: 31154404
pii: 95/0/46
doi: 10.3899/jrheum.190119
doi:

Substances chimiques

HLA-C Antigens 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

46-50

Subventions

Organisme : NIAMS NIH HHS
ID : R01 AR050511
Pays : United States

Auteurs

Darren D O'Rielly (DD)

From the Memorial University, St. John's, Newfoundland, Canada; Arthritis Research Centre for Epidemiology, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK; University of Michigan, Ann Arbor, Michigan, USA. Darren.orielly@med.mun.ca.
D.D. O'Rielly, PhD, FCCMG, Memorial University; M. Jani, MB ChB, MRCP, MSc, PhD, Arthritis Research Centre for Epidemiology, Centre for Musculoskeletal Research, The University of Manchester; P. Rahman, MD, Professor of Medicine and Rheumatology, Memorial University, St. John's, Newfoundland; J.T. Elder, MD, Kirk D. Wuepper Professor of Molecular Genetic Dermatology, University of Michigan. Darren.orielly@med.mun.ca.

Meghna Jani (M)

From the Memorial University, St. John's, Newfoundland, Canada; Arthritis Research Centre for Epidemiology, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK; University of Michigan, Ann Arbor, Michigan, USA.
D.D. O'Rielly, PhD, FCCMG, Memorial University; M. Jani, MB ChB, MRCP, MSc, PhD, Arthritis Research Centre for Epidemiology, Centre for Musculoskeletal Research, The University of Manchester; P. Rahman, MD, Professor of Medicine and Rheumatology, Memorial University, St. John's, Newfoundland; J.T. Elder, MD, Kirk D. Wuepper Professor of Molecular Genetic Dermatology, University of Michigan.

Proton Rahman (P)

From the Memorial University, St. John's, Newfoundland, Canada; Arthritis Research Centre for Epidemiology, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK; University of Michigan, Ann Arbor, Michigan, USA.
D.D. O'Rielly, PhD, FCCMG, Memorial University; M. Jani, MB ChB, MRCP, MSc, PhD, Arthritis Research Centre for Epidemiology, Centre for Musculoskeletal Research, The University of Manchester; P. Rahman, MD, Professor of Medicine and Rheumatology, Memorial University, St. John's, Newfoundland; J.T. Elder, MD, Kirk D. Wuepper Professor of Molecular Genetic Dermatology, University of Michigan.

James T Elder (JT)

From the Memorial University, St. John's, Newfoundland, Canada; Arthritis Research Centre for Epidemiology, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK; University of Michigan, Ann Arbor, Michigan, USA.
D.D. O'Rielly, PhD, FCCMG, Memorial University; M. Jani, MB ChB, MRCP, MSc, PhD, Arthritis Research Centre for Epidemiology, Centre for Musculoskeletal Research, The University of Manchester; P. Rahman, MD, Professor of Medicine and Rheumatology, Memorial University, St. John's, Newfoundland; J.T. Elder, MD, Kirk D. Wuepper Professor of Molecular Genetic Dermatology, University of Michigan.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Allèles › The Genetics of Psoriasis and Psoriatic Arthritis.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses papulosquameuses › Psoriasis › Arthrite psoriasique › The Genetics of Psoriasis and Psoriatic Arthritis.
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › The Genetics of Psoriasis and Psoriatic Arthritis.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › The Genetics of Psoriasis and Psoriatic Arthritis.
questionsmedicales.fr › Phénomènes génétiques › Génotype › The Genetics of Psoriasis and Psoriatic Arthritis.
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › Antigènes HLA-C › The Genetics of Psoriasis and Psoriatic Arthritis.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Genetics of Psoriasis and Psoriatic Arthritis.
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › The Genetics of Psoriasis and Psoriatic Arthritis.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses papulosquameuses › Psoriasis › The Genetics of Psoriasis and Psoriatic Arthritis.