Mitochondrial dysfunction causes Ca
Animals
Antimycin A
/ pharmacology
Blotting, Western
Caenorhabditis elegans
Caenorhabditis elegans Proteins
/ metabolism
Calcium
/ metabolism
Disease Models, Animal
Extracellular Matrix
/ drug effects
Furin
/ metabolism
Matrix Metalloproteinases
/ metabolism
Mitochondria
/ drug effects
Muscle, Skeletal
/ drug effects
Muscular Dystrophy, Animal
Muscular Dystrophy, Duchenne
Antimycin A
DMD
Furin
MMP
collagen
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
pubmed:
5
6
2019
medline:
2
6
2020
entrez:
5
6
2019
Statut:
ppublish
Résumé
Mitochondrial dysfunction impairs muscle health and causes subsequent muscle wasting. This study explores the role of mitochondrial dysfunction as an intramuscular signal for the extracellular matrix (ECM)-based proteolysis and, consequentially, muscle cell dystrophy. We found that inhibition of the mitochondrial electron transport chain causes paralysis as well as muscle structural damage in the nematode
Identifiants
pubmed: 31162948
doi: 10.1096/fj.201802298R
pmc: PMC6662967
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Antimycin A
642-15-9
Furin
EC 3.4.21.75
Matrix Metalloproteinases
EC 3.4.24.-
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9540-9550Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N015894/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P025781/1
Pays : United Kingdom
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