Unraveling structural insights of ribokinase from Leishmania donovani.

Amino Acid Sequence Binding Sites Crystallography, X-Ray Leishmania donovani / enzymology Models, Molecular Nucleotides / metabolism Phosphates / pharmacology Phosphotransferases (Alcohol Group Acceptor) / chemistry Protein Conformation
Leishmania donovani Nucleotide-binding site Protein crystallography Ribokinase Substrate-binding pocket

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
01 Sep 2019
Historique:
received: 15 03 2019
revised: 29 05 2019
accepted: 01 06 2019
pubmed: 7 6 2019
medline: 31 12 2019
entrez: 7 6 2019
Statut: ppublish

Résumé

Ribokinase (RK) is an ATP dependent sugar kinase that enables the entry of ribose in the metabolism. Leishmania accumulates ribose into the cytosol through hydrolysis of nucleosides and by transport from the extracellular environment. Activation by RK is critical to mobilize the ribose into the metabolism of Leishmania. To understand the catalytic role, the crystal structure of RK (LdRK) from L. donovani was determined in the apo and complex forms with several nucleotides (ATP, AMPPCP and ADP) in the presence of Na

Identifiants

DOI: 10.1016/j.ijbiomac.2019.06.001 PMID: 31170491
pubmed: 31170491
pii: S0141-8130(19)31946-4
doi: 10.1016/j.ijbiomac.2019.06.001
pii:
doi:

Substances chimiques

Nucleotides 0
Phosphates 0
Phosphotransferases (Alcohol Group Acceptor) EC 2.7.1.-
ribokinase EC 2.7.1.15

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

253-265

Informations de copyright

Copyright © 2019. Published by Elsevier B.V.

Auteurs

Santhosh Gatreddi (S)

Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad 500 046, Telangana, India.

Vijaykumar Pillalamarri (V)

CSIR-Indian Institute of Chemical Technology, Applied Biology, Hyderabad 500 007, Telangana, India; Academy of Scientific and Innovative Research (AcSIR), Rafi Marg, New Delhi 110001, India.

Dileep Vasudevan (D)

Institute of Life Sciences, Bhubaneswar 751023, Odisha, India.

Anthony Addlagatta (A)

CSIR-Indian Institute of Chemical Technology, Applied Biology, Hyderabad 500 007, Telangana, India; Academy of Scientific and Innovative Research (AcSIR), Rafi Marg, New Delhi 110001, India.

Insaf Ahmed Qureshi (IA)

Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad 500 046, Telangana, India. Electronic address: insaf@uohyd.ac.in.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Unraveling structural insights of ribokinase...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Unraveling structural insights of ribokinase...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Unraveling structural insights of ribokinase...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Leishmania › Leishmania donovani › Unraveling structural insights of ribokinase...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Unraveling structural insights of ribokinase...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Unraveling structural insights of ribokinase...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du phosphore › Acides du phosphore › Acides phosphoriques › Phosphates › Unraveling structural insights of ribokinase...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Alcohol Group Acceptor) › Unraveling structural insights of ribokinase...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Unraveling structural insights of ribokinase...