Leishmania infantum induces expression of the negative regulatory checkpoint, CTLA-4, by human naïve CD8
Adult
CD8-Positive T-Lymphocytes
/ immunology
CTLA-4 Antigen
/ genetics
Cytokines
/ immunology
Female
Granzymes
/ immunology
Humans
Interleukin-10
/ immunology
Leishmania braziliensis
/ physiology
Leishmania infantum
/ physiology
Leishmaniasis
/ immunology
Leishmaniasis, Visceral
/ immunology
Male
Principal Component Analysis
Leishmania
CD8 lymphocytes
CTLA-4
checkpoint
cytokines
immune regulation
Journal
Parasite immunology
ISSN: 1365-3024
Titre abrégé: Parasite Immunol
Pays: England
ID NLM: 7910948
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
10
04
2019
revised:
30
05
2019
accepted:
02
06
2019
pubmed:
8
6
2019
medline:
13
2
2020
entrez:
8
6
2019
Statut:
ppublish
Résumé
CD8 We have evaluated the expression of granzyme A, inflammatory and anti-inflammatory cytokines, as well as CTLA-4 by human naïve CD8 These results may help explain why patients with the visceral clinical form present a weaker cellular response and, consequently, a worse outcome of the disease. The use of CTLA-4 checkpoint inhibitors may emerge as a potential immunotherapy to ameliorate the immune response in visceral leishmaniasis patients.
Substances chimiques
CTLA-4 Antigen
0
CTLA4 protein, human
0
Cytokines
0
IL10 protein, human
0
Interleukin-10
130068-27-8
Granzymes
EC 3.4.21.-
GZMA protein, human
EC 3.4.21.78
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12659Informations de copyright
© 2019 John Wiley & Sons Ltd.
Références
Gollob KJ, Viana AG, Dutra WO. Immunoregulation in human American leishmaniasis: balancing pathology and protection. Parasite Immunol. 2014;36(8):367-376.
Reiner SL, Locksley RM. Lessons from Leishmania: a model for investigations of CD4+ subset differentiation. Infect Agents Dis. 1992;1(1):33-42.
Cardoso TM, Machado A, Costa DL, et al. Protective and pathological functions of CD8+ T cells in Leishmania braziliensis infection. Infect Immun. 2015;83(3):898-906.
Faria DR, Gollob KJ, Barbosa J, et al. Decreased in situ expression of interleukin-10 receptor is correlated with the exacerbated inflammatory and cytotoxic responses observed in mucosal leishmaniasis. Infect Immun. 2005;73(12):7853-7859.
Kaushal H, Bras-Goncalves R, Negi NS, Lemesre JL, Papierok G, Salotra P. Role of CD8(+) T cells in protection against Leishmania donovani infection in healed Visceral Leishmaniasis individuals. BMC Infect Dis. 2014;14:653.
Scott P, Novais FO. Cutaneous leishmaniasis: immune responses in protection and pathogenesis. Nat Rev Immunol. 2016;16(9):581-592.
Wilson ME, Jeronimo SM, Pearson RD. Immunopathogenesis of infection with the visceralizing Leishmania species. Microb Pathog. 2005;38(4):147-160.
Burza S, Croft SL, Boelaert M. Leishmaniasis. Lancet. 2018;392(10151):951-970.
Magalhaes LM, Viana A, Chiari E, Galvao LM, Gollob KJ, Dutra WO. Differential activation of human monocytes and lymphocytes by distinct strains of Trypanosoma cruzi. PLoS Negl Trop Dis. 2015;9(7):e0003816.
Goncalves R, Vieira ER, Melo MN, Gollob KJ, Mosser DM, Tafuri WL. A sensitive flow cytometric methodology for studying the binding of L chagasi to canine peritoneal macrophages. BMC Infect Dis. 2005;5:39.
Viana AG, Magalhaes L, Giunchetti RC, Dutra WO, Gollob KJ. Infection of human monocytes with Leishmania infantum strains induces a downmodulated response when compared with infection with Leishmania braziliensis. Front Immunol. 2017;8:1896.
Metsalu T, Vilo J. ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap. Nucleic Acids Res. 2015;43(W1):W566-W570.
Chavez-Galan L, Arenas-Del Angel MC, Zenteno E, Chavez R, Lascurain R. Cell death mechanisms induced by cytotoxic lymphocytes. Cell Mol Immunol. 2009;6(1):15-25.
Pentcheva-Hoang T, Egen JG, Wojnoonski K, Allison JP. B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse. Immunity. 2004;21(3):401-413.
Gollob KJ, Antonelli LR, Faria DR, Keesen TS, Dutra WO. Immunoregulatory mechanisms and CD4-CD8- (double negative) T cell subpopulations in human cutaneous leishmaniasis: a balancing act between protection and pathology. Int Immunopharmacol. 2008;8(10):1338-1343.
Faria DR, Souza PE, Duraes FV, et al. Recruitment of CD8(+) T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis. Parasite Immunol. 2009;31(8):432-439.
Gautam S, Kumar R, Singh N, et al. CD8 T cell exhaustion in human visceral leishmaniasis. J Infect Dis. 2014;209(2):290-299.
Nateghi Rostami M, Keshavarz H, Edalat R, et al. CD8+ T cells as a source of IFN-gamma production in human cutaneous leishmaniasis. PLoS Negl Trop Dis. 2010;4(10):e845.
McCoy KD, Le Gros G. The role of CTLA-4 in the regulation of T cell immune responses. Immunol Cell Biol. 1999;77(1):1-10.
Murphy ML, Cotterell SE, Gorak PM, Engwerda CR, Kaye PM. Blockade of CTLA-4 enhances host resistance to the intracellular pathogen, Leishmania donovani. J Immunol. 1998;161(8):4153-4160.
Gomes NA, Gattass CR, Barreto-De-Souza V, Wilson ME, DosReis GA. TGF-beta mediates CTLA-4 suppression of cellular immunity in murine kalaazar. J Immunol. 2000;164(4):2001-2008.
Bacellar O, Faria D, Nascimento M, et al. Interleukin 17 production among patients with American cutaneous leishmaniasis. J Infect Dis. 2009;200(1):75-78.
Nascimento MS, Carregaro V, Lima-Junior DS, et al. Interleukin 17A acts synergistically with interferon gamma to promote protection against Leishmania infantum infection. J Infect Dis. 2015;211(6):1015-1026.
Peruhype-Magalhaes V, Martins-Filho OA, Prata A, et al. Mixed inflammatory/regulatory cytokine profile marked by simultaneous raise of interferon-gamma and interleukin-10 and low frequency of tumour necrosis factor-alpha(+) monocytes are hallmarks of active human visceral Leishmaniasis due to Leishmania chagasi infection. Clin Exp Immunol. 2006;146(1):124-132.
Oliveira WN, Ribeiro LE, Schrieffer A, Machado P, Carvalho EM, Bacellar O. The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis. Cytokine. 2014;66(2):127-132.
Belkaid Y, Hoffmann KF, Mendez S, et al. The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure. J Exp Med. 2001;194(10):1497-1506.