Role of brain imaging in disorders of brain-gut interaction: a Rome Working Team Report.
brain/gut interaction
functional bowel disorder
irritable bowel syndrome
magnetic resonance imaging
Journal
Gut
ISSN: 1468-3288
Titre abrégé: Gut
Pays: England
ID NLM: 2985108R
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
05
02
2019
revised:
18
03
2019
accepted:
24
03
2019
pubmed:
9
6
2019
medline:
26
9
2019
entrez:
9
6
2019
Statut:
ppublish
Résumé
Imaging of the living human brain is a powerful tool to probe the interactions between brain, gut and microbiome in health and in disorders of brain-gut interactions, in particular IBS. While altered signals from the viscera contribute to clinical symptoms, the brain integrates these interoceptive signals with emotional, cognitive and memory related inputs in a non-linear fashion to produce symptoms. Tremendous progress has occurred in the development of new imaging techniques that look at structural, functional and metabolic properties of brain regions and networks. Standardisation in image acquisition and advances in computational approaches has made it possible to study large data sets of imaging studies, identify network properties and integrate them with non-imaging data. These approaches are beginning to generate brain signatures in IBS that share some features with those obtained in other often overlapping chronic pain disorders such as urological pelvic pain syndromes and vulvodynia, suggesting shared mechanisms. Despite this progress, the identification of preclinical vulnerability factors and outcome predictors has been slow. To overcome current obstacles, the creation of consortia and the generation of standardised multisite repositories for brain imaging and metadata from multisite studies are required.
Identifiants
pubmed: 31175206
pii: gutjnl-2019-318308
doi: 10.1136/gutjnl-2019-318308
pmc: PMC6999847
mid: NIHMS1043705
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1701-1715Subventions
Organisme : Medical Research Council
ID : G0600965
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK096606
Pays : United States
Organisme : Medical Research Council
ID : G0701706
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : P50 DK064539
Pays : United States
Organisme : Medical Research Council
ID : G0300195
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK048351
Pays : United States
Informations de copyright
© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: EAM is on the scientific advisory boards of Axial Biotherapeutics, Bloom Science, Danone, Viome, Whole Biome and Mahana Therapeutics.
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