Quantification of breast tissue density: Correlation between single-sided portable NMR and micro-CT measurements.

Adipose Tissue / diagnostic imaging Adult Aged Breast / diagnostic imaging Breast Density Breast Neoplasms / diagnostic imaging Female Humans Least-Squares Analysis Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Mammography Mastectomy Middle Aged X-Ray Microtomography
Breast imaging Diffusion Mammographic density Single-sided portable NMR Spin-relaxation rate constants T(1) and T(2) μCT

Journal

Magnetic resonance imaging
ISSN: 1873-5894
Titre abrégé: Magn Reson Imaging
Pays: Netherlands
ID NLM: 8214883

Informations de publication

Date de publication:
10 2019
Historique:
received: 04 02 2019
revised: 23 05 2019
accepted: 06 06 2019
pubmed: 10 6 2019
medline: 3 1 2020
entrez: 10 6 2019
Statut: ppublish

Résumé

Mammographic density (MD) is a strong independent risk factor for breast cancer. Traditional screening for MD using X-ray mammography involves ionising radiation, which is not suitable for young women, those with previous radiation exposure, or those having undergone a partial mastectomy. Therefore, alternative approaches for MD screening that do not involve ionising radiation will be important as the clinical use of MD increases, and as more frequent MD testing becomes desirable for research purposes. We have previously demonstrated the potential utility of spin relaxation-based, single-sided portable-NMR measurements for the purpose of MD quantification. We present here a more refined analysis by quantifying breast tissue density in excised samples on a continuous scale (0% to 100% fibroglandular tissue content) using micro-CT (μCT), and comparing the results to spin-relaxation and diffusion portable-NMR measurements of the same samples. μCT analysis of mammary tissues containing high- and low-MD (HMD and LMD, respectively) regions had Hounsfield Unit (HU) histograms with a bimodal pattern, with HMD regions exhibiting significantly higher HU values than LMD regions. Quantitative MD (%HMD) values obtained using μCT exhibited an excellent correlation with portable-NMR results, namely longitudinal spin-relaxation time constants (T

Identifiants

DOI: 10.1016/j.mri.2019.06.006 PMID: 31176808
pubmed: 31176808
pii: S0730-725X(19)30082-7
doi: 10.1016/j.mri.2019.06.006
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

111-120

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Xuan Huang (X)

Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia; Translational Research Institute, Woolloongabba, Australia; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT), Brisbane, Australia.

Tonima S Ali (TS)

Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia; School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology (QUT), Brisbane, Australia.

Teresa Nano (T)

Greenslopes Private Hospital, Greenslopes, Australia.

Tony Blick (T)

Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia; Translational Research Institute, Woolloongabba, Australia.

Brian Wan-Chi Tse (BW)

Preclincal Imaging Facility, Translational Research Institute, Woolloongabba, Australia.

Kamil Sokolowski (K)

Preclincal Imaging Facility, Translational Research Institute, Woolloongabba, Australia.

Monique C Tourell (MC)

Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia; School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology (QUT), Brisbane, Australia.

Thomas Lloyd (T)

Radiology Department, Princess Alexandra Hospital, Woolloongabba, Australia.

Erik W Thompson (EW)

Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia; Translational Research Institute, Woolloongabba, Australia; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT), Brisbane, Australia; University of Melbourne, Department of Surgery, St. Vincent's Hospital, Melbourne, Australia.

Konstantin I Momot (KI)

Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia; School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology (QUT), Brisbane, Australia.

Honor J Hugo (HJ)

Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Australia; Translational Research Institute, Woolloongabba, Australia; School of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT), Brisbane, Australia. Electronic address: honor.hugo@qut.edu.au.

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Classifications MeSH

questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Quantification of breast tissue density:...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Quantification of breast tissue density:...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Quantification of breast tissue density:...
questionsmedicales.fr › Régions du corps › Région mammaire › Quantification of breast tissue density:...
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Densité mammaire › Quantification of breast tissue density:...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Quantification of breast tissue density:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Quantification of breast tissue density:...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de régression › Méthode des moindres carrés › Quantification of breast tissue density:...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Quantification of breast tissue density:...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Quantification of breast tissue density:...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Radiographie › Mammographie › Quantification of breast tissue density:...
questionsmedicales.fr › Procédures de chirurgie opératoire › Mastectomie › Quantification of breast tissue density:...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Quantification of breast tissue density:...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › Microtomographie aux rayons X › Quantification of breast tissue density:...