Age Mosaicism across Multiple Scales in Adult Tissues.
Aging
/ genetics
Animals
Cellular Senescence
/ genetics
Cilia
/ metabolism
Endothelial Cells
/ metabolism
Female
Fibroblasts
/ metabolism
Insulin-Secreting Cells
/ metabolism
Liver
/ metabolism
Mice
Mice, Inbred Strains
Mosaicism
Neurons
/ metabolism
Organ Specificity
/ genetics
Pancreas
/ metabolism
aging
cell longevity
correlated multi-scale multi-modal microscopy
islets of Langerhans
multi-isotope imaging mass spectroscopy
primary cilium
Journal
Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170
Informations de publication
Date de publication:
06 08 2019
06 08 2019
Historique:
received:
14
06
2018
revised:
18
10
2018
accepted:
11
05
2019
pubmed:
11
6
2019
medline:
2
10
2020
entrez:
11
6
2019
Statut:
ppublish
Résumé
Most neurons are not replaced during an animal's lifetime. This nondividing state is characterized by extreme longevity and age-dependent decline of key regulatory proteins. To study the lifespans of cells and proteins in adult tissues, we combined isotope labeling of mice with a hybrid imaging method (MIMS-EM). Using
Identifiants
pubmed: 31178361
pii: S1550-4131(19)30250-5
doi: 10.1016/j.cmet.2019.05.010
pmc: PMC7289515
mid: NIHMS1576358
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
343-351.e3Subventions
Organisme : NIGMS NIH HHS
ID : P41 GM103412
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS096786
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS027177
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK120447
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM126829
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA014195
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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