DNA methylation, colon cancer and Mediterranean diet: results from the EPIC-Italy cohort.
Colon cancer
DNA methylation
Mediterranean diet
inflammation
meet-in-the-middle
Journal
Epigenetics
ISSN: 1559-2308
Titre abrégé: Epigenetics
Pays: United States
ID NLM: 101265293
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
pubmed:
11
6
2019
medline:
28
5
2020
entrez:
11
6
2019
Statut:
ppublish
Résumé
The biological mechanisms through which adherence to Mediterranean Diet (MD) protects against colon cancer (CC) are poorly understood. Evidence suggests that chronic inflammation may be implicated in the pathway. Both diet and CC are related to epigenetic regulation. We performed a nested case-control study on 161 pairs from the Italian component of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, in which we looked for the methylation signals in DNA extracted from leucocytes associated with both CC and MD in 995 CpGs located in 48 inflammation genes. The DNA methylation signals detected in this analysis were validated in a subgroup of 47 case-control pairs and further replicated (where validated) in 95 new pairs by means of pyrosequencing. Among the CpG sites selected
Identifiants
pubmed: 31179817
doi: 10.1080/15592294.2019.1629230
pmc: PMC6691992
doi:
Substances chimiques
Core Binding Factor Alpha 1 Subunit
0
RUNX2 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
977-988Subventions
Organisme : Medical Research Council
ID : MR/L01341X/1
Pays : United Kingdom
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