Robo2 regulates synaptic oxytocin content by affecting actin dynamics.
Actins
/ metabolism
Animals
Animals, Genetically Modified
Fluorescence Recovery After Photobleaching
Green Fluorescent Proteins
/ genetics
Intracellular Signaling Peptides and Proteins
/ genetics
Microscopy, Fluorescence, Multiphoton
Mutation
Oxytocin
/ genetics
Receptors, Immunologic
/ genetics
Signal Transduction
/ genetics
Synapses
/ metabolism
Zebrafish
/ genetics
Zebrafish Proteins
/ genetics
cdc42 GTP-Binding Protein
/ genetics
arginine-vasopressin
developmental biology
hypothalamus
neuroendocrine
neurohypophysis
neuroscience
oxytocin
synapse
zebrafish
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
10 06 2019
10 06 2019
Historique:
received:
30
01
2019
accepted:
08
06
2019
pubmed:
11
6
2019
medline:
3
3
2020
entrez:
11
6
2019
Statut:
epublish
Résumé
The regulation of neuropeptide level at the site of release is essential for proper neurophysiological functions. We focused on a prominent neuropeptide, oxytocin (OXT) in the zebrafish as an in vivo model to visualize and quantify OXT content at the resolution of a single synapse. We found that OXT-loaded synapses were enriched with polymerized actin. Perturbation of actin filaments by either cytochalasin-D or conditional Cofilin expression resulted in decreased synaptic OXT levels. Genetic loss of
Identifiants
pubmed: 31180321
doi: 10.7554/eLife.45650
pii: 45650
pmc: PMC6590984
doi:
pii:
Substances chimiques
Actins
0
Intracellular Signaling Peptides and Proteins
0
Receptors, Immunologic
0
Slit3 protein, zebrafish
0
Zebrafish Proteins
0
robo2 protein, zebrafish
0
Green Fluorescent Proteins
147336-22-9
Oxytocin
50-56-6
cdc42 GTP-Binding Protein
EC 3.6.5.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Israel Science Foundation
ID : 1511/16
Pays : International
Organisme : Israel Science Foundation
ID : 2137/16
Pays : International
Organisme : Minerva Foundation
ID : Minerva Stiftung
Pays : International
Organisme : United States-Israel Binational Science Foundation
ID : 2017325
Pays : International
Organisme : Minerva Foundation
ID : (Minerva Stiftung)
Pays : International
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2019, Anbalagan et al.
Déclaration de conflit d'intérêts
SA, JB, MG, LG, RR, TD, ES, GL No competing interests declared
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