Identification of compounds that rescue otic and myelination defects in the zebrafish
Animals
Ear, Inner
/ drug effects
Embryo, Nonmammalian
/ drug effects
Gene Expression Regulation, Developmental
/ drug effects
Molecular Structure
Mutation
Myelin Sheath
/ drug effects
Peripheral Nervous System
/ drug effects
Proteoglycans
/ genetics
Receptors, G-Protein-Coupled
/ genetics
Schwann Cells
/ drug effects
Signal Transduction
/ drug effects
Small Molecule Libraries
/ chemistry
Zebrafish
Zebrafish Proteins
/ genetics
Adgrg6 (Gpr126)
adhesion GPCR
chemoinformatics
developmental biology
inner ear
myelination
neuroscience
phenotypic screening
zebrafish
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
10 06 2019
10 06 2019
Historique:
received:
04
01
2019
accepted:
08
06
2019
pubmed:
11
6
2019
medline:
3
3
2020
entrez:
11
6
2019
Statut:
epublish
Résumé
Adgrg6 (Gpr126) is an adhesion class G protein-coupled receptor with a conserved role in myelination of the peripheral nervous system. In the zebrafish, mutation of
Identifiants
pubmed: 31180326
doi: 10.7554/eLife.44889
pii: 44889
pmc: PMC6598766
doi:
pii:
Substances chimiques
Proteoglycans
0
Receptors, G-Protein-Coupled
0
Small Molecule Libraries
0
Zebrafish Proteins
0
stx7l protein, zebrafish
0
vcanb protein, zebrafish
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Union Seventh Framework Programme
ID : Grant agreement no. 612347
Pays : International
Organisme : Biotechnology and Biological Sciences Research Council
ID : ALERT14 equipment award BB/M012522/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : Project grant BB/J003050/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0700091
Pays : United Kingdom
Organisme : European Union's Seventh Framework Programme
ID : Grant agreement no. 612347
Pays : International
Organisme : Medical Research Council
ID : G0802527
Pays : United Kingdom
Organisme : University of Sheffield
ID : PhD studentship 314420
Pays : International
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R50581X/1
Pays : United Kingdom
Organisme : Wellcome
ID : VIP award 084551
Pays : International
Organisme : Biotechnology and Biological Sciences Research Council
ID : Project grant BB/M01021X/1
Pays : United Kingdom
Informations de copyright
© 2019, Diamantopoulou et al.
Déclaration de conflit d'intérêts
ED, SB, Ad, AA, CH, LA, VG, GW No competing interests declared, TW Reviewing editor, eLife
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