Solid-State NMR Investigations of the MHC II Transmembrane Domains: Topological Equilibria and Lipid Interactions.
Fatty acyl chain order parameter
Helix topology
Highly specific protein–lipid interaction
Solid-state NMR
Supported lipid bilayer
Transmembrane dimer
Journal
The Journal of membrane biology
ISSN: 1432-1424
Titre abrégé: J Membr Biol
Pays: United States
ID NLM: 0211301
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
18
02
2019
accepted:
25
05
2019
pubmed:
13
6
2019
medline:
18
6
2020
entrez:
13
6
2019
Statut:
ppublish
Résumé
The major histocompatibility complex class II (MHC II) membrane proteins are key players in the adaptive immune response. An aberrant function of these molecules is associated with a large number of autoimmune diseases such as diabetes type I and chronic inflammatory diseases. The MHC class II is assembled from DQ alpha 1 and DQ beta 1 which come together as a heterodimer through GXXXG-mediated protein-protein interactions and a highly specific protein-sphingomyelin-C18 interaction motif located on DQA1. This association can have important consequences in regulating the function of these membrane proteins. Here, we investigated the structure and topology of the DQA1 and DQB1 transmembrane helical domains by CD-, oriented
Identifiants
pubmed: 31187155
doi: 10.1007/s00232-019-00071-8
pii: 10.1007/s00232-019-00071-8
doi:
Substances chimiques
HLA-DQ alpha-Chains
0
HLA-DQ beta-Chains
0
HLA-DQA1 antigen
0
HLA-DQB1 antigen
0
Lipid Bilayers
0
Phosphatidylcholines
0
1-palmitoyl-2-oleoylphosphatidylcholine
TE895536Y5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
371-384Subventions
Organisme : Agence Nationale de la Recherche
ID : 10-BLAN-731
Pays : International
Organisme : Agence Nationale de la Recherche
ID : 12-BSV5-0012
Pays : International
Organisme : Agence Nationale de la Recherche
ID : 14-CE34-0001-01
Pays : International
Organisme : Agence Nationale de la Recherche
ID : 15-CE11-0017-01
Pays : International
Organisme : Agence Nationale de la Recherche
ID : 10-LABX-0026_CSC
Pays : International
Références
Biochim Biophys Acta. 2005 Aug 5;1724(3):315-23
pubmed: 15961233
Biochim Biophys Acta. 2000 Nov 10;1469(3):159-95
pubmed: 11063882
Biochemistry. 2004 Aug 17;43(32):10502-12
pubmed: 15301548
Biol Cell. 2009 Sep;101(9):495-509
pubmed: 19566487
J Pept Sci. 2014 Jul;20(7):526-36
pubmed: 24909405
Nature. 1984 Jul 19-25;310(5974):235-8
pubmed: 6379465
J Biomol NMR. 2009 Dec;45(4):373-87
pubmed: 19823773
Biochemistry. 2000 Jul 25;39(29):8347-52
pubmed: 10913240
Biophys J. 2010 May 19;98(9):1864-72
pubmed: 20441750
Biophys J. 2013 Aug 6;105(3):699-710
pubmed: 23931318
J Chem Biol. 2008 Nov;1(1-4):63-77
pubmed: 19568799
Ann Hum Biol. 2010 Nov;37(6):778-88
pubmed: 20569042
Eur Biophys J. 2014 Nov;43(10-11):499-507
pubmed: 25182242
Front Cell Dev Biol. 2016 Jun 24;4:65
pubmed: 27595096
Immunol Rev. 2012 Nov;250(1):144-57
pubmed: 23046127
Mol Biosyst. 2010 Sep;6(9):1650-61
pubmed: 20379596
J Biol Chem. 2003 Aug 15;278(33):31303-11
pubmed: 12782631
Biophys J. 2001 Oct;81(4):2251-6
pubmed: 11566795
Nature. 2012 Jan 09;481(7382):525-9
pubmed: 22230960
Ann N Y Acad Sci. 2007 Sep;1110:92-8
pubmed: 17911424
Biochim Biophys Acta. 2010 Feb;1798(2):258-65
pubmed: 19596252
Chem Phys Lipids. 2012 Apr;165(3):282-301
pubmed: 22366307
Biophys J. 2002 May;82(5):2476-86
pubmed: 11964235
Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):E119-26
pubmed: 25548160
Biochim Biophys Acta. 2010 Feb;1798(2):223-7
pubmed: 19716800
J Magn Reson. 2000 Jan;142(1):97-101
pubmed: 10617439
Biophys J. 2003 May;84(5):3052-60
pubmed: 12719236
Biochim Biophys Acta. 2014 Aug;1838(8):2066-70
pubmed: 24796501
Biochim Biophys Acta. 2015 Sep;1848(9):1886-96
pubmed: 25791349
Biochemistry. 2019 Jun 18;58(24):2782-2795
pubmed: 31120242
Mol Immunol. 2016 Jun;74:59-70
pubmed: 27148821
Front Immunol. 2013 Oct 10;4:321
pubmed: 24133494
J Mol Biol. 2000 Feb 25;296(3):911-9
pubmed: 10677291
Biochemistry. 2011 May 10;50(18):3784-95
pubmed: 21456583
Biochim Biophys Acta. 2015 Apr;1853(4):775-80
pubmed: 25261705
Biochim Biophys Acta. 2009 Jul;1788(7):1482-96
pubmed: 19409370
J Biol Chem. 2014 Apr 25;289(17):11695-703
pubmed: 24619409
Hum Immunol. 2019 Jan;80(1):5-14
pubmed: 30102939
Biophys J. 2000 Nov;79(5):2644-56
pubmed: 11053137
Biochim Biophys Acta. 2015 Jun;1851(6):844-56
pubmed: 25241941
Eur Biophys J. 2007 Dec;37(1):71-80
pubmed: 17492281
Biophys Chem. 2011 Jan;153(2-3):115-25
pubmed: 21145159
J Biol Chem. 2002 Nov 29;277(48):46504-11
pubmed: 12237308
Traffic. 2008 Apr;9(4):597-607
pubmed: 18182008
Trends Biochem Sci. 2013 Nov;38(11):576-84
pubmed: 24054463
J Biomol NMR. 2015 May;62(1):53-61
pubmed: 25749871
Structure. 2006 Dec;14(12):1731-40
pubmed: 17161364
Biomolecules. 2018 Apr 18;8(2):
pubmed: 29670065
Solid State Nucl Magn Reson. 2014 Jul-Sep;61-62:15-8
pubmed: 24746715
Mol Cell Biol. 2006 Nov;26(21):8011-21
pubmed: 16940185
Chem Phys Lipids. 2019 Mar;219:58-71
pubmed: 30711343
Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1421-6
pubmed: 19164538
Biophys J. 2018 Sep 18;115(6):1033-1044
pubmed: 30195937
Biophys J. 2014 Aug 19;107(4):901-11
pubmed: 25140425
J Biol Chem. 2006 Oct 13;281(41):30365-72
pubmed: 16835230
Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1224-8
pubmed: 9990005
Adv Exp Med Biol. 2019;1117:33-64
pubmed: 30980352
Biochimie. 2009 Jun;91(6):734-43
pubmed: 19455745