"Dual Disease" TgAD/GSS mice exhibit enhanced Alzheimer's disease pathology and reveal PrP


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
12 06 2019
Historique:
received: 14 08 2018
accepted: 13 03 2019
entrez: 14 6 2019
pubmed: 14 6 2019
medline: 21 10 2020
Statut: epublish

Résumé

To address the question of cross-talk between prion protein (PrP) and Alzheimer's disease (AD), we generated TgAD/GSS mice that develop amyloid-β (Aβ) plaques of AD and PrP (specifically mutated PrP

Identifiants

pubmed: 31189938
doi: 10.1038/s41598-019-44317-w
pii: 10.1038/s41598-019-44317-w
pmc: PMC6562043
doi:

Substances chimiques

Amyloid beta-Peptides 0
PrPC Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

8524

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Auteurs

Kefeng Qin (K)

Department of Neurology, The University of Chicago Pritzker School of Medicine, Chicago, USA.

Lili Zhao (L)

Department of Neurology, The University of Chicago Pritzker School of Medicine, Chicago, USA.

Crystal Gregory (C)

Department of Neurology, The University of Chicago Pritzker School of Medicine, Chicago, USA.

Ani Solanki (A)

Department of Neurology, The University of Chicago Pritzker School of Medicine, Chicago, USA.

James A Mastrianni (JA)

Department of Neurology, The University of Chicago Pritzker School of Medicine, Chicago, USA. jmastria@uchicago.edu.

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