[Autoantibody-associated schizophreniform psychoses: pathophysiology, diagnostics, and treatment].
Autoantikörper-assoziierte schizophreniforme Psychosen: Pathophysiologie, Diagnostik und Therapie.
Antibody
Autoimmune encephalitis
Autoimmune psychosis
Limbic encephalitis
Schizophrenia
Journal
Der Nervenarzt
ISSN: 1433-0407
Titre abrégé: Nervenarzt
Pays: Germany
ID NLM: 0400773
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
pubmed:
15
6
2019
medline:
12
9
2019
entrez:
15
6
2019
Statut:
ppublish
Résumé
In the context of secondary, possibly organic schizophreniform psychoses, autoantibody(AB)-associated autoimmune encephalitis (AE) plays an increasingly important role. If this is suspected, clinical investigations, including laboratory, magnetic resonance imaging, electroencephalography and cerebrospinal fluid (CSF) analyses are recommended. The AB screening should include the most frequent ABs against neuronal cell surface antigens (NMDA receptor [R], CASPR2, LGI1, AMPA-R, GABAB-R), intracellular antigens (Hu, Ri, Yo, CV2/CRMP5, Ma2[Ta], amphiphysin, GAD65), thyroid tissue (TG, TPO, TRAK), and antinuclear antigens (ANAs). The ABs against cell surface antigens and GAD65 should be examined directly in serum and CSF. Less frequent ABs can be looked for in a second step. Furthermore, immunofluorescence tests on brain slices of rodents may identify previously unknown ABs. The detection of ABs in combination with further findings can lead to the diagnosis of AE which implies new therapeutic opportunities with immunomodulators.
Identifiants
pubmed: 31197396
doi: 10.1007/s00115-019-0735-1
pii: 10.1007/s00115-019-0735-1
doi:
Substances chimiques
Autoantibodies
0
Immunologic Factors
0
Types de publication
Journal Article
Langues
ger
Sous-ensembles de citation
IM
Pagination
745-761Références
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