Impaired frequencies and function of platelets and tissue remodeling in chronic Chagas disease.
Adolescent
Adult
Aged
Aged, 80 and over
Blood Platelets
/ metabolism
Chagas Cardiomyopathy
/ metabolism
Chagas Disease
/ metabolism
Chronic Disease
Endothelin-1
/ metabolism
Female
Fibrinogen
/ metabolism
Humans
Inflammation
/ metabolism
Male
Middle Aged
P-Selectin
/ metabolism
Procollagen
/ metabolism
Trypanosoma cruzi
/ pathogenicity
Young Adult
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
23
11
2018
accepted:
29
05
2019
entrez:
15
6
2019
pubmed:
15
6
2019
medline:
7
2
2020
Statut:
epublish
Résumé
Chronic inflammation, as a consequence of the persistent infection with Trypanosoma cruzi, leads to continuous activation of the immune system in patients with chronic Chagas disease. We have previously shown that increased sera levels of soluble P-selectin are associated with the severity of the cardiomyopathy distinctive of chronic Chagas disease. In this study, we explored the expression of biomarkers of platelet and endothelial activation, tissue remodeling, and mediators of the coagulation cascade in patients at different clinical stages of chronic Chagas heart disease. The frequencies of activated platelets, measured by the expression of CD41a and CD62P were decreased in patients with chronic Chagas disease compared with those in uninfected subjects, with an inverse association with disease severity. Platelet activation in response to adenosine diphosphate was also decreased in T. cruzi-infected subjects. A major proportion of T. cruzi infected subjects showed increased serum levels of fibrinogen. Patients with severe cardiac dysfunction showed increased levels of endothelin-1 and normal values of procollagen I. In conclusion, chronic infection with T. cruzi induced hemostatic alterations, even in those patients who do not yet present cardiac symptoms.
Identifiants
pubmed: 31199841
doi: 10.1371/journal.pone.0218260
pii: PONE-D-18-33658
pmc: PMC6570032
doi:
Substances chimiques
Endothelin-1
0
P-Selectin
0
Procollagen
0
Fibrinogen
9001-32-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0218260Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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