Genomewide Elucidation of Drug Resistance Mechanisms for Systemically Used Antifungal Drugs Amphotericin B, Caspofungin, and Voriconazole in the Budding Yeast.

Amphotericin B / pharmacology Antifungal Agents / pharmacology Candida albicans / drug effects Caspofungin / pharmacology Drug Resistance, Fungal / genetics Microbial Sensitivity Tests Saccharomyces cerevisiae / drug effects Saccharomyces cerevisiae Proteins / genetics Saccharomycetales / drug effects Voriconazole / pharmacology
amphotericin B antifungal agents caspofungin drug resistance genomics multidrug resistance voriconazole

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
09 2019
Historique:
received: 02 11 2018
accepted: 03 06 2019
pubmed: 19 6 2019
medline: 7 7 2020
entrez: 19 6 2019
Statut: epublish

Résumé

There are only a few antifungal drugs used systemically in treatment, and invasive fungal infections that are resistant to these drugs are an emerging problem in health care. In this study, we performed a high-copy-number genomic DNA (gDNA) library screening to find and characterize genes that reduce susceptibility to amphotericin B, caspofungin, and voriconazole in

Identifiants

DOI: 10.1128/AAC.02268-18 PMID: 31209012 PMC: PMC6709451
pubmed: 31209012
pii: AAC.02268-18
doi: 10.1128/AAC.02268-18
pmc: PMC6709451
pii:
doi:

Substances chimiques

Antifungal Agents 0
Saccharomyces cerevisiae Proteins 0
Amphotericin B 7XU7A7DROE
Caspofungin F0XDI6ZL63
Voriconazole JFU09I87TR

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2019 American Society for Microbiology.

Références

J Biol Chem. 1999 Jan 22;274(4):1934-41
pubmed: 9890948
Nature. 1998 Jul 9;394(6689):192-5
pubmed: 9671304
Mycoses. 2013 Nov;56(6):638-45
pubmed: 23551865
Antimicrob Agents Chemother. 1997 Aug;41(8):1832-4
pubmed: 9257773
Cell Rep. 2013 Feb 21;3(2):577-85
pubmed: 23416056
N Engl J Med. 2004 Sep 30;351(14):1391-402
pubmed: 15459300
Clin Infect Dis. 1995 Aug;21(2):361-9
pubmed: 8562745
Antimicrob Agents Chemother. 2014;58(4):2409-14
pubmed: 24395234
J Clin Microbiol. 2008 Jul;46(7):2389-92
pubmed: 18448691
Proc Natl Acad Sci U S A. 2004 May 11;101(19):7329-34
pubmed: 15123810
Med Mycol. 2008 May;46(3):231-9
pubmed: 18404551
Clin Infect Dis. 2008 Jun 15;46(12):1813-21
pubmed: 18462102
Genetics. 2007 Sep;177(1):17-30
pubmed: 17603101
Am J Med. 1988 May;84(5):826-32
pubmed: 3284339
Eur J Med Chem. 2010 Oct;45(10):4435-45
pubmed: 20675019
Genetics. 2007 Mar;175(3):1105-15
pubmed: 17194787
J Neurosci. 2009 Sep 2;29(35):10843-54
pubmed: 19726642
PLoS Genet. 2014 Dec 18;10(12):e1004894
pubmed: 25521586
Antimicrob Agents Chemother. 2012 Aug;56(8):4223-32
pubmed: 22615281
PLoS One. 2015 Sep 29;10(9):e0139306
pubmed: 26418026
Biochim Biophys Acta. 1994 Sep 13;1219(1):205-10
pubmed: 8086466
J Membr Biol. 2010 Dec;238(1-3):1-20
pubmed: 21085940
J Biol Chem. 2003 Oct 17;278(42):40612-20
pubmed: 12902335
Curr Genet. 1987;12(7):497-501
pubmed: 2452027
Mol Biol Cell. 2000 Jun;11(6):1989-2005
pubmed: 10848624
J Med Microbiol. 2017 Mar;66(2):213-216
pubmed: 27959780
Antimicrob Agents Chemother. 2003 Sep;47(9):2717-24
pubmed: 12936965
Am J Med. 1997 Aug;103(2):106-13
pubmed: 9274893
Yeast. 1995 Apr 15;11(4):355-60
pubmed: 7785336
FEMS Yeast Res. 2006 Sep;6(6):924-36
pubmed: 16911514
Nat Rev Microbiol. 2007 Jan;5(1):13-28
pubmed: 17160002
Nat Chem Biol. 2014 May;10(5):400-6
pubmed: 24681535
Yeast. 1998 Sep 30;14(13):1189-97
pubmed: 9791890
Antimicrob Agents Chemother. 2008 Oct;52(10):3597-603
pubmed: 18694951
Microbiology. 2009 Jan;155(Pt 1):268-278
pubmed: 19118367
Yeast. 2007 Oct;24(10):913-9
pubmed: 17583893
Fungal Genet Biol. 2010 Feb;47(2):117-26
pubmed: 19770064
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2234-9
pubmed: 22308411
Clin Microbiol Infect. 2014 Jun;20 Suppl 6:54-9
pubmed: 24372680
Antimicrob Agents Chemother. 2008 Oct;52(10):3701-9
pubmed: 18694952
Clin Infect Dis. 2003 Mar 1;36(5):630-7
pubmed: 12594645
Yeast. 1994 Mar;10(3):341-53
pubmed: 8017104
EMBO J. 2000 Jun 1;19(11):2515-24
pubmed: 10835350
Sci Rep. 2015 May 12;5:9685
pubmed: 25965669
FEMS Microbiol Lett. 2015 Jan;362(3):1-8
pubmed: 25673653
Cell Death Differ. 2006 Mar;13(3):363-73
pubmed: 16397583
Antimicrob Agents Chemother. 2015 Oct;59(10):6629-33
pubmed: 26248365
Yeast. 2010 Jun;27(6):317-25
pubmed: 20148390
Med Mycol. 2002 Dec;40(6):581-91
pubmed: 12521122
Biochim Biophys Acta. 2009 May;1788(5):1044-50
pubmed: 19285482
J Antimicrob Chemother. 2003 Mar;51(3):513-21
pubmed: 12615851
Antimicrob Agents Chemother. 2010 Sep;54(9):3578-83
pubmed: 20547793
Mol Biol Cell. 2001 Jun;12(6):1633-44
pubmed: 11408574

Auteurs

Cigdem Balkan (C)

Department of Molecular Biology and Genetics, Izmir Institute of Technology, Urla, Izmir, Turkey.

Ilkcan Ercan (I)

Department of Molecular Biology and Genetics, Izmir Institute of Technology, Urla, Izmir, Turkey.

Esin Isik (E)

Department of Molecular Biology and Genetics, Izmir Institute of Technology, Urla, Izmir, Turkey.

Esra Sahin Akdeniz (E)

Department of Molecular Biology and Genetics, Izmir Institute of Technology, Urla, Izmir, Turkey.

Orhan Balcioglu (O)

Department of Molecular Biology and Genetics, Izmir Institute of Technology, Urla, Izmir, Turkey.

Marie Kodedová (M)

Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.

Olga Zimmermannová (O)

Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.

Muhammed Dundar (M)

Department of Medical Biology and Genetics, School of Medicine, Inonu University, Malatya, Turkey.

Hana Sychrová (H)

Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.

Ahmet Koc (A)

Department of Molecular Biology and Genetics, Izmir Institute of Technology, Urla, Izmir, Turkey ahmet.koc@inonu.edu.tr.
Department of Medical Biology and Genetics, School of Medicine, Inonu University, Malatya, Turkey.
ORCID: 0000-0003-3484-2137

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Lactones › Amphotéricine B › Genomewide Elucidation of Drug Resistance...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antifongiques › Genomewide Elucidation of Drug Resistance...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Candida › Candida albicans › Genomewide Elucidation of Drug Resistance...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › Échinocandines › Caspofungine › Genomewide Elucidation of Drug Resistance...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance des champignons aux médicaments › Genomewide Elucidation of Drug Resistance...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Genomewide Elucidation of Drug Resistance...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Genomewide Elucidation of Drug Resistance...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Saccharomyces cerevisiae › Genomewide Elucidation of Drug Resistance...
questionsmedicales.fr › Eucaryotes › Champignons › Ascomycota › Saccharomycetales › Genomewide Elucidation of Drug Resistance...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Triazoles › Voriconazole › Genomewide Elucidation of Drug Resistance...