Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns.
Antimalarials
/ pharmacology
Artemisinins
/ pharmacology
Asia, Southeastern
Biodiversity
Drug Resistance
/ genetics
Epidemiological Monitoring
Genome, Protozoan
/ genetics
Genotype
Geography, Medical
Malaria, Falciparum
/ drug therapy
Plasmodium falciparum
/ drug effects
Polymorphism, Single Nucleotide
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
17 06 2019
17 06 2019
Historique:
received:
28
04
2018
accepted:
17
04
2019
entrez:
19
6
2019
pubmed:
19
6
2019
medline:
10
7
2019
Statut:
epublish
Résumé
Estimates of Plasmodium falciparum migration may inform strategies for malaria elimination. Here we elucidate fine-scale parasite population structure and infer recent migration across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nucleotide polymorphisms called in 1722 samples from 54 districts. IBD estimates are consistent with isolation-by-distance. We observe greater sharing of larger IBD segments between artemisinin-resistant parasites versus sensitive parasites, which is consistent with the recent spread of drug resistance. Our IBD analyses reveal actionable patterns, including isolated parasite populations, which may be prioritized for malaria elimination, as well as asymmetrical migration identifying potential sources and sinks of migrating parasites.
Identifiants
pubmed: 31209259
doi: 10.1038/s41467-019-10121-3
pii: 10.1038/s41467-019-10121-3
pmc: PMC6572796
doi:
Substances chimiques
Antimalarials
0
Artemisinins
0
artemisinin
9RMU91N5K2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2665Subventions
Organisme : NIAID NIH HHS
ID : R01 AI145852
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI101713
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI125579
Pays : United States
Organisme : NIAID NIH HHS
ID : R03 AI101680
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI110820
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI129386
Pays : United States
Organisme : World Health Organization
ID : 001
Pays : International
Investigateurs
Harald Noedl
(H)
Wasif A Khan
(WA)
Paul Newton
(P)
Myat P Kyaw
(MP)
Nicholas J White
(NJ)
Arjen M Dondorp
(AM)
Nicholas P Day
(NP)
Charles J Woodrow
(CJ)
Mehul Dhorda
(M)
M Abul Faiz
(MA)
Rick M Fairhurst
(RM)
Pharath Lim
(P)
Rupam Tripura
(R)
Mayfong Mayxay
(M)
Ye Htut
(Y)
Francois Nosten
(F)
Aung Pyae Phyo
(AP)
Sasithon Pukrittayakamee
(S)
Tran Tinh Hien
(TT)
Nguyen Thanh Thuy Nhien
(NTT)
Olugbenga A Mokuolu
(OA)
Caterina I Fanello
(CI)
Marie A Onyamboko
(MA)
Références
Malar J. 2008 Oct 21;7:212
pubmed: 18937873
Bioinformatics. 2013 Jul 01;29(13):i180-8
pubmed: 23812983
J Infect Dis. 2015 Nov 15;212(10):1629-35
pubmed: 25910630
PLoS Genet. 2016 May 27;12(5):e1006059
pubmed: 27232753
N Engl J Med. 2014 Jul 31;371(5):411-23
pubmed: 25075834
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
PLoS Genet. 2016 Jan 15;12(1):e1005703
pubmed: 26771578
Antimicrob Agents Chemother. 2015 Aug;59(8):4631-43
pubmed: 26014942
Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6526-E6535
pubmed: 29946025
Evolution. 1993 Feb;47(1):264-279
pubmed: 28568097
Genome Biol. 2011;12(4):R33
pubmed: 21463505
Nat Genet. 2013 Jun;45(6):648-55
pubmed: 23624527
Nat Genet. 2015 Mar;47(3):226-34
pubmed: 25599401
Malar J. 2012 Oct 26;11:355
pubmed: 23101492
Science. 2012 Oct 12;338(6104):267-70
pubmed: 23066082
Infect Genet Evol. 2013 Oct;19:164-75
pubmed: 23871774
Nat Rev Genet. 2011 Sep 16;12(10):703-14
pubmed: 21921926
PLoS One. 2012;7(12):e52236
pubmed: 23272227
Mol Biol Evol. 2020 Apr 1;37(4):943-951
pubmed: 31778174
PLoS One. 2013;8(3):e57689
pubmed: 23520478
BMC Genomics. 2014 Aug 26;15:719
pubmed: 25159520
Nat Genet. 2014 Aug;46(8):818-25
pubmed: 24974849
Malar J. 2011 Dec 20;10:378
pubmed: 22185615
Malar J. 2015 Jul 22;14:283
pubmed: 26194795
Malar J. 2009 Jul 14;8:155
pubmed: 19602241
Genetics. 1997 Apr;145(4):1219-28
pubmed: 9093870
Am J Trop Med Hyg. 2012 Mar;86(3):403-408
pubmed: 22403308
Mol Biol Evol. 2012 Feb;29(2):473-86
pubmed: 21984068
Gigascience. 2015 Feb 25;4:7
pubmed: 25722852
Mitochondrion. 2015 Sep;24:9-21
pubmed: 26149324
Travel Med Infect Dis. 2013 Jan-Feb;11(1):15-22
pubmed: 23478045
PLoS Biol. 2013;11(5):e1001555
pubmed: 23667324
Nat Genet. 2016 Jan;48(1):94-100
pubmed: 26642242
Mol Ecol. 2012 Jun;21(12):2839-46
pubmed: 22574758
PLoS One. 2011;6(5):e19283
pubmed: 21603629
Mol Biol Evol. 2000 Oct;17(10):1467-82
pubmed: 11018154
PLoS Biol. 2005 Oct;3(10):e335
pubmed: 16144426
Am J Hum Genet. 2016 Jan 7;98(1):116-26
pubmed: 26748515
Lancet Infect Dis. 2018 Mar;18(3):337-345
pubmed: 29398391
Nat Rev Genet. 2006 Oct;7(10):771-80
pubmed: 16983373
Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):7067-72
pubmed: 25941365
Am J Hum Genet. 2012 Nov 2;91(5):809-22
pubmed: 23103233
Infect Genet Evol. 2015 Jul;33:189-96
pubmed: 25952567
PLoS Genet. 2017 Oct 27;13(10):e1007065
pubmed: 29077712
Elife. 2016 Mar 04;5:
pubmed: 26943619
N Engl J Med. 2009 Jul 30;361(5):455-67
pubmed: 19641202
Genome Biol. 2017 Apr 28;18(1):78
pubmed: 28454557
Nature. 2012 Jul 19;487(7407):375-9
pubmed: 22722859
PLoS Genet. 2006 Dec;2(12):e190
pubmed: 17194218
PLoS Genet. 2019 Jan 14;15(1):e1007908
pubmed: 30640906
Lancet Infect Dis. 2017 May;17(5):491-497
pubmed: 28161569
Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12222-7
pubmed: 20566870
Am J Hum Genet. 2010 Apr 9;86(4):526-39
pubmed: 20303063
Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15942-7
pubmed: 16243969
Genetics. 2000 Jun;155(2):945-59
pubmed: 10835412
Genome Res. 2009 Sep;19(9):1655-64
pubmed: 19648217
Mol Biol Evol. 2005 Dec;22(12):2362-74
pubmed: 16093566
Genetics. 2013 Jun;194(2):459-71
pubmed: 23535385
Mol Ecol. 2013 Jan;22(2):273-85
pubmed: 23121253
Mol Ecol. 2009 Dec;18(23):4734-56
pubmed: 19878454
Nat Genet. 2007 Jan;39(1):113-9
pubmed: 17159979