Genome-wide association study implicates CHRNA2 in cannabis use disorder.
Age of Onset
Alleles
Attention Deficit Disorder with Hyperactivity
/ genetics
Brain
/ metabolism
Case-Control Studies
Chromosomes, Human, Pair 8
/ genetics
Cognition
/ physiology
Cohort Studies
Confounding Factors, Epidemiologic
Denmark
Educational Status
Female
Gene Expression Profiling
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Iceland
Male
Marijuana Abuse
/ genetics
Multifactorial Inheritance
Nerve Tissue Proteins
/ biosynthesis
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Receptors, Nicotinic
/ biosynthesis
Schizophrenia
/ genetics
Smoking
/ genetics
Transcriptome
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
07
11
2018
accepted:
25
04
2019
pubmed:
19
6
2019
medline:
19
7
2019
entrez:
19
6
2019
Statut:
ppublish
Résumé
Cannabis is the most frequently used illicit psychoactive substance worldwide; around one in ten users become dependent. The risk for cannabis use disorder (CUD) has a strong genetic component, with twin heritability estimates ranging from 51 to 70%. Here we performed a genome-wide association study of CUD in 2,387 cases and 48,985 controls, followed by replication in 5,501 cases and 301,041 controls. We report a genome-wide significant risk locus for CUD (P = 9.31 × 10
Identifiants
pubmed: 31209380
doi: 10.1038/s41593-019-0416-1
pii: 10.1038/s41593-019-0416-1
pmc: PMC7596896
mid: NIHMS1622118
doi:
Substances chimiques
CHRNA2 protein, human
0
Nerve Tissue Proteins
0
Receptors, Nicotinic
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1066-1074Subventions
Organisme : NIDA NIH HHS
ID : R01 DA034076
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH094432
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH109514
Pays : United States
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