Polyphenol Effects on Splenic Cytokine Response in Post-Weaning Contactin 1-Overexpressing Transgenic Mice.
cellular and molecular rehabilitation
contactins
cytokine
neonatal immunity
polyphenols
splenocytes
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
12 Jun 2019
12 Jun 2019
Historique:
received:
17
05
2019
revised:
03
06
2019
accepted:
07
06
2019
entrez:
20
6
2019
pubmed:
20
6
2019
medline:
30
11
2019
Statut:
epublish
Résumé
In mice, postnatal immune development has previously been investigated, and evidence of a delayed maturation of the adaptive immune response has been detected. In this study, the effects of red grape polyphenol oral administration on the murine immune response were explored using pregnant mice (TAG/F3 transgenic and wild type (wt) mice) as the animal model. The study was performed during pregnancy as well as during lactation until postnatal day 8. Suckling pups from polyphenol-administered dams as well as day 30 post-weaning pups (dietary-administered with polyphenols) were used. Polyphenol effects were evaluated, measuring splenic cytokine secretion. Phorbol myristate acetate-activated splenocytes underwent the highest cytokine production at day 30 in both wt and TAG/F3 mice. In the latter, release of interferon (IFN)-γ and tumor necrosis factor (TNF)-α was found to be higher than in the wt counterpart. In this context, polyphenols exerted modulating activities on day 30 TAG/F3 mice, inducing release of interleukin (IL)-10 in hetero mice while abrogating release of IL-2, IFN-γ, TNF-α, IL-6, and IL-4 in homo and hetero mice. Polyphenols are able to prevent the development of an inflammatory/allergic profile in postnatal TAG/F3 mice.
Sections du résumé
BACKGROUND
BACKGROUND
In mice, postnatal immune development has previously been investigated, and evidence of a delayed maturation of the adaptive immune response has been detected.
METHODS
METHODS
In this study, the effects of red grape polyphenol oral administration on the murine immune response were explored using pregnant mice (TAG/F3 transgenic and wild type (wt) mice) as the animal model. The study was performed during pregnancy as well as during lactation until postnatal day 8. Suckling pups from polyphenol-administered dams as well as day 30 post-weaning pups (dietary-administered with polyphenols) were used. Polyphenol effects were evaluated, measuring splenic cytokine secretion.
RESULTS
RESULTS
Phorbol myristate acetate-activated splenocytes underwent the highest cytokine production at day 30 in both wt and TAG/F3 mice. In the latter, release of interferon (IFN)-γ and tumor necrosis factor (TNF)-α was found to be higher than in the wt counterpart. In this context, polyphenols exerted modulating activities on day 30 TAG/F3 mice, inducing release of interleukin (IL)-10 in hetero mice while abrogating release of IL-2, IFN-γ, TNF-α, IL-6, and IL-4 in homo and hetero mice.
CONCLUSION
CONCLUSIONS
Polyphenols are able to prevent the development of an inflammatory/allergic profile in postnatal TAG/F3 mice.
Identifiants
pubmed: 31212848
pii: molecules24122205
doi: 10.3390/molecules24122205
pmc: PMC6631041
pii:
doi:
Substances chimiques
Contactin 1
0
Cytokines
0
Polyphenols
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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