Rosmarinic acid suppresses Alzheimer's disease development by reducing amyloid β aggregation by increasing monoamine secretion.
Alzheimer Disease
/ genetics
Amyloid beta-Peptides
/ genetics
Animals
Antioxidants
/ pharmacology
Biogenic Monoamines
/ metabolism
Brain
/ drug effects
Cinnamates
/ pharmacology
Depsides
/ pharmacology
Female
Gene Expression Profiling
/ methods
Gene Ontology
Mice, Inbred C57BL
Mice, Transgenic
Monoamine Oxidase
/ genetics
Norepinephrine
/ metabolism
Oligonucleotide Array Sequence Analysis
/ methods
Protein Aggregation, Pathological
/ prevention & control
Substantia Nigra
/ drug effects
Ventral Tegmental Area
/ drug effects
Rosmarinic Acid
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
18 06 2019
18 06 2019
Historique:
received:
18
12
2018
accepted:
03
06
2019
entrez:
20
6
2019
pubmed:
20
6
2019
medline:
27
10
2020
Statut:
epublish
Résumé
A new mechanism is revealed by which a polyphenol, rosmarinic acid (RA), suppresses amyloid β (Aβ) accumulation in mice. Here we examined the brains of mice (Alzheimer's disease model) using DNA microarray analysis and revealed that the dopamine (DA)-signaling pathway was enhanced in the group fed RA versus controls. In the cerebral cortex, the levels of monoamines, such as norepinephrine, 3,4-dihydroxyphenylacetic acid, DA, and levodopa, increased after RA feeding. The expression of DA-degrading enzymes, such as monoamine oxidase B (Maob), was significantly downregulated in the substantia nigra and ventral tegmental area, both DA synthesis regions. Following in vitro studies showing that monoamines inhibited Aβ aggregation, this in vivo study, in which RA intake increased concentration of monoamine by reducing Maob gene expression, builds on that knowledge by demonstrating that monoamines suppress Aβ aggregation. In conclusion, RA-initiated monoamine increase in the brain may beneficially act against AD.
Identifiants
pubmed: 31213631
doi: 10.1038/s41598-019-45168-1
pii: 10.1038/s41598-019-45168-1
pmc: PMC6581955
doi:
Substances chimiques
Amyloid beta-Peptides
0
Antioxidants
0
Biogenic Monoamines
0
Cinnamates
0
Depsides
0
Monoamine Oxidase
EC 1.4.3.4
Norepinephrine
X4W3ENH1CV
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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