Targetable genetic alterations of
Animals
Blotting, Western
Cell Line
Cell Survival
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
/ genetics
High-Throughput Nucleotide Sequencing
Humans
Immunoglobulins
/ metabolism
Lymphoma, Large B-Cell, Diffuse
/ genetics
Male
Mice
Mice, Nude
Signal Transduction
/ genetics
Transcription Factor 4
/ genetics
Xenograft Model Antitumor Assays
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
19 06 2019
19 06 2019
Historique:
received:
28
09
2018
revised:
31
01
2019
accepted:
15
05
2019
entrez:
21
6
2019
pubmed:
21
6
2019
medline:
1
7
2020
Statut:
ppublish
Résumé
The activated B cell (ABC-like) subtype of diffuse large B cell lymphoma (DLBCL) is characterized by chronic activation of signaling initiated by immunoglobulin μ (IgM). By analyzing the DNA copy number profiles of 1000 DLBCL tumors, we identified gains of 18q21.2 as the most frequent genetic alteration in ABC-like DLBCL. Using integrative analysis of matched gene expression profiling data, we found that the
Identifiants
pubmed: 31217338
pii: 11/497/eaav5599
doi: 10.1126/scitranslmed.aav5599
pmc: PMC6724184
mid: NIHMS1047498
pii:
doi:
Substances chimiques
Immunoglobulins
0
TCF4 protein, human
0
Transcription Factor 4
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : R01 CA210250
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA191222
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197566
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA201380
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA036727
Pays : United States
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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