Assessing nicotine dependence using an oral nicotine free-choice paradigm in mice.

Animals Behavior, Addictive / psychology Choice Behavior / drug effects Dose-Response Relationship, Drug Drug Interactions Female Male Mice Mice, Knockout Nicotine / administration & dosage Nucleus Accumbens / metabolism Quinine / pharmacology Receptors, Nicotinic / genetics Self Administration Sex Characteristics Substance Withdrawal Syndrome Tobacco Use Disorder / psychology Tyrosine 3-Monooxygenase / metabolism Varenicline / pharmacology
Addiction Dependence Nicotine Oral self-administration Two-bottle choice Withdrawal

Journal

Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217

Informations de publication

Date de publication:
10 2019
Historique:
received: 17 01 2019
revised: 03 06 2019
accepted: 12 06 2019
pubmed: 21 6 2019
medline: 22 7 2020
entrez: 21 6 2019
Statut: ppublish

Résumé

Models to assess the addictive-like properties of nicotine in mice are limited. Therefore, we aimed to characterize and validate an addiction index by using an oral nicotine free-choice paradigm in mice. Adult C57BL/6J, DBA/2J, or genetically modified mice carrying deletions for nicotinic acetylcholine receptor (nAChR) subunits, (n = 8-10/sex/group) were given a choice of water or nicotine (10-960 μg/ml) solution using a two-bottle free-choice (2BC) paradigm. In general, oral nicotine intake and preference were higher in female mice compared to males. Absence of nicotine led to withdrawal, and intermittent access resulted in an escalation in consumption and greater nicotine withdrawal than continuous exposure. Additionally, oral nicotine consumption increased nucleus accumbens tyrosine hydroxylase levels. While β2 and α6 KO mice showed a significant decrease in nicotine intake, deletion of α5 nAChRs increased nicotine consumption at high concentrations. Deletion of the α7 subunit altered the observed sex difference in nicotine consumption, with females consuming less than males. The α4β2 partial agonist varenicline decreased oral nicotine consumption. Although addition of quinine to the nicotine solution lowered nicotine intake, mice primed with nicotine did not lower their intake after quinine addition. Nicotine deprivation followed by re-exposure showed increased nicotine consumption, and DBA/2J mice consumed less nicotine compared to C57BL/6J. We validated the mouse 2BC paradigm to study nicotine's addictive-like properties including nicotine intake, preference, withdrawal, and escalation of nicotine consumption during binge drinking or after reinstatement of a deprivation period.

Identifiants

DOI: 10.1016/j.neuropharm.2019.107669 PMID: 31220484 PMC: PMC6697382
pubmed: 31220484
pii: S0028-3908(19)30229-1
doi: 10.1016/j.neuropharm.2019.107669
pmc: PMC6697382
mid: NIHMS1532601
pii:
doi:

Substances chimiques

Receptors, Nicotinic 0
Nicotine 6M3C89ZY6R
Quinine A7V27PHC7A
Tyrosine 3-Monooxygenase EC 1.14.16.2
Varenicline W6HS99O8ZO

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

107669

Subventions

Organisme : NIDA NIH HHS
ID : P30 DA033934
Pays : United States
Organisme : NIDA NIH HHS
ID : P50 DA036105
Pays : United States
Organisme : NIDA NIH HHS
ID : P50 DA005274
Pays : United States
Organisme : NIDA NIH HHS
ID : R25 DA036915
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA032246
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

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Auteurs

Deniz Bagdas (D)

Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 23298-0613, USA; The Center for the Study for Tobacco Products, Virginia Commonwealth University, Richmond, VA, 23298-0613, USA.

Clare M Diester (CM)

Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 23298-0613, USA.

Jason Riley (J)

Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 23298-0613, USA.

Moriah Carper (M)

Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 23298-0613, USA.

Yasmin Alkhlaif (Y)

Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 23298-0613, USA.

Dana AlOmari (D)

Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 23298-0613, USA.

Hala Alayoubi (H)

Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 23298-0613, USA.

Justin L Poklis (JL)

Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 23298-0613, USA.

M Imad Damaj (MI)

Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, 23298-0613, USA; The Center for the Study for Tobacco Products, Virginia Commonwealth University, Richmond, VA, 23298-0613, USA. Electronic address: m.damaj@vcuhealth.org.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Assessing nicotine dependence using an oral...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement impulsif › Comportement compulsif › Comportement toxicomaniaque › Assessing nicotine dependence using an oral...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Pensée (activité mentale) › Prise de décision › Comportement de choix › Assessing nicotine dependence using an oral...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Assessing nicotine dependence using an oral...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Interactions médicamenteuses › Assessing nicotine dependence using an oral...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Assessing nicotine dependence using an oral...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Assessing nicotine dependence using an oral...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Nicotine › Assessing nicotine dependence using an oral...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Striatum ventral › Noyau accumbens › Assessing nicotine dependence using an oral...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Quinine › Assessing nicotine dependence using an oral...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteurs nicotiniques › Assessing nicotine dependence using an oral...
questionsmedicales.fr › Thérapeutique › Autoadministration › Assessing nicotine dependence using an oral...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Caractères sexuels › Assessing nicotine dependence using an oral...
questionsmedicales.fr › Troubles mentaux › Troubles liés à une substance › Syndrome de sevrage › Assessing nicotine dependence using an oral...
questionsmedicales.fr › Troubles mentaux › Troubles liés à une substance › Trouble lié au tabagisme › Assessing nicotine dependence using an oral...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Protéines à fer non hème › Tyrosine 3-monooxygenase › Assessing nicotine dependence using an oral...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoxalines › Varénicline › Assessing nicotine dependence using an oral...