Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology.
Animals
Arteries
/ immunology
Atherosclerosis
/ immunology
Consensus
Energy Metabolism
/ immunology
Humans
Immune System
/ immunology
Immunomodulation
Inflammation
/ immunology
Inflammation Mediators
/ immunology
Macrophages
/ immunology
Monocytes
/ immunology
Plaque, Atherosclerotic
Signal Transduction
T-Lymphocytes
/ immunology
Immune system
Inflammation
Metabolism
Vascular
Atherosclerosis
Journal
Cardiovascular research
ISSN: 1755-3245
Titre abrégé: Cardiovasc Res
Pays: England
ID NLM: 0077427
Informations de publication
Date de publication:
01 07 2019
01 07 2019
Historique:
received:
17
12
2018
revised:
19
05
2019
accepted:
18
06
2019
pubmed:
23
6
2019
medline:
17
6
2020
entrez:
23
6
2019
Statut:
ppublish
Résumé
Inflammation is an important driver of atherosclerosis, and the favourable outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial revealed the large potential of anti-inflammatory drugs for the treatment of cardiovascular disease, especially in patients with a pro-inflammatory constitution. However, the complex immune reactions driving inflammation in the vascular wall in response to an atherosclerotic microenvironment are still being unravelled. Novel insights into the cellular processes driving immunity and inflammation revealed that alterations in intracellular metabolic pathways are strong drivers of survival, growth, and function of immune cells. Therefore, this position paper presents a brief overview of the recent developments in the immunometabolism field, focusing on its role in atherosclerosis. We will also highlight the potential impact of immunometabolic markers and targets in clinical cardiovascular medicine.
Identifiants
pubmed: 31228191
pii: 5522025
doi: 10.1093/cvr/cvz166
pmc: PMC6681176
doi:
Substances chimiques
Inflammation Mediators
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1385-1392Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL080472
Pays : United States
Organisme : British Heart Foundation
ID : PG/17/15/32845
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/14/18/30724
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/10/50/28434
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/13/24/30115
Pays : United Kingdom
Informations de copyright
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.
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