Role of antigen specific T and B cells in systemic and mucosal immune responses in ETEC and Shigella infections, and their potential to serve as correlates of protection in vaccine development.
Antibodies, Bacterial
/ biosynthesis
B-Lymphocytes
/ drug effects
Clinical Trials as Topic
Congresses as Topic
Diarrhea
/ epidemiology
Dysentery, Bacillary
/ epidemiology
Enterotoxigenic Escherichia coli
/ drug effects
Escherichia coli Infections
/ epidemiology
Escherichia coli Vaccines
/ administration & dosage
Humans
Immunity, Cellular
/ drug effects
Immunity, Mucosal
/ drug effects
Immunization
/ methods
Immunogenicity, Vaccine
Immunologic Memory
Shigella
/ drug effects
Shigella Vaccines
/ administration & dosage
T-Lymphocytes
/ drug effects
B cells
Correlates of protection (CoP)
Enterotoxigenic Escherichia coli (ETEC)
IgA
IgG
Immunocorrelate
Mucosal antibodies
Shigella
T cells
Journal
Vaccine
ISSN: 1873-2518
Titre abrégé: Vaccine
Pays: Netherlands
ID NLM: 8406899
Informations de publication
Date de publication:
07 08 2019
07 08 2019
Historique:
received:
07
12
2018
revised:
07
03
2019
accepted:
19
03
2019
pubmed:
25
6
2019
medline:
17
9
2020
entrez:
25
6
2019
Statut:
ppublish
Résumé
The generation of robust systemic and mucosal antibody and cell-mediated immune (CMI) responses that are protective, long-lasting, and can quickly be recalled upon subsequent re-exposure to the cognate antigen is the key to the development of effective vaccine candidates. These responses, whether they represent mechanistic or non-mechanistic immunological correlates of protection, usually entail the activation of T cell memory and effector subsets (T-CMI) and induction of long-lasting memory B cells. However, for ETEC and Shigella, the precise role of these key immune cells in primary and secondary (anamnestic) immune responses remains ill-defined. A workshop to address immune correlates for ETEC and Shigella, in general, and to elucidate the mechanistic role of T-cell subsets and B-cells, both systemically and in the mucosal microenvironment, in the development of durable protective immunity against ETEC and Shigella was held at the recent 2nd Vaccines against Shigella and ETEC (VASE) conference in June 2018. This report is a summary of the presentations and the discussion that ensued at the workshop.
Identifiants
pubmed: 31230883
pii: S0264-410X(19)30372-X
doi: 10.1016/j.vaccine.2019.03.040
pmc: PMC7413037
pii:
doi:
Substances chimiques
Antibodies, Bacterial
0
Escherichia coli Vaccines
0
Shigella Vaccines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4787-4793Subventions
Organisme : NIAID NIH HHS
ID : R01 AI036525
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI082655
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI109776
Pays : United States
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
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