Promoter-dependent nuclear RNA degradation ensures cell cycle-specific gene expression.
Mitosis
RNA decay
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
2019
2019
Historique:
received:
06
12
2018
accepted:
29
04
2019
entrez:
27
6
2019
pubmed:
27
6
2019
medline:
27
6
2019
Statut:
epublish
Résumé
Cell cycle progression depends on phase-specific gene expression. Here we show that the nuclear RNA degradation machinery plays a lead role in promoting cell cycle-dependent gene expression by triggering promoter-dependent co-transcriptional RNA degradation. Single molecule quantification of RNA abundance in different phases of the cell cycle indicates that relative curtailment of gene expression in certain phases is attained even when transcription is not completely inhibited. When nuclear ribonucleases are deleted, transcription of the
Identifiants
pubmed: 31240249
doi: 10.1038/s42003-019-0441-3
pii: 441
pmc: PMC6572803
doi:
Substances chimiques
Axl2 protein, S cerevisiae
0
Membrane Glycoproteins
0
RNA, Messenger
0
RNA, Nuclear
0
Saccharomyces cerevisiae Proteins
0
TOA1 protein, S cerevisiae
0
Transcription Factor TFIIA
0
RNT1 protein, S cerevisiae
EC 3.1.26.3
Ribonuclease III
EC 3.1.26.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
211Subventions
Organisme : CIHR
Pays : Canada
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing interests.
Références
Genetics. 2014 Jan;196(1):65-90
pubmed: 24395825
Cell. 2013 May 23;153(5):1000-11
pubmed: 23706738
Nucleic Acids Res. 2012 Aug;40(15):7507-17
pubmed: 22576366
PLoS Genet. 2015 Feb 13;11(2):e1005000
pubmed: 25680180
Mol Biol Cell. 2008 May;19(5):1932-41
pubmed: 18287520
Nat Biotechnol. 2009 Jul;27(7):652-8
pubmed: 19581875
J Biol Chem. 2008 Mar 7;283(10):6040-9
pubmed: 18160399
Genes Dev. 2006 Aug 15;20(16):2266-78
pubmed: 16912276
Curr Biol. 2005 Jan 26;15(2):140-5
pubmed: 15668170
Mol Cell Biol. 2003 Aug;23(16):5502-15
pubmed: 12897126
Nature. 2004 Nov 25;432(7016):517-22
pubmed: 15565157
Mol Cell. 1998 Jul;2(1):65-73
pubmed: 9702192
Yeast. 1998 Jan 30;14(2):115-32
pubmed: 9483801
Wiley Interdiscip Rev RNA. 2019 May;10(3):e1521
pubmed: 30548404
Cell. 2011 Dec 23;147(7):1473-83
pubmed: 22196725
Mol Cell. 2009 Oct 9;36(1):88-98
pubmed: 19818712
Methods Mol Biol. 2011;734:63-79
pubmed: 21468985
FEMS Yeast Res. 2017 Jan;17(1):
pubmed: 27993914
Annu Rev Genet. 2005;39:69-94
pubmed: 16285853
Nat Methods. 2018 Jan;15(1):81-89
pubmed: 29131164
J Cell Biol. 2000 Dec 25;151(7):1501-12
pubmed: 11134078
Genome Res. 2012 Jul;22(7):1350-9
pubmed: 22466169
Mol Cell. 2017 Mar 2;65(5):787-800.e5
pubmed: 28190770
Mol Cell Biol. 2002 Jul;22(13):4792-802
pubmed: 12052886
Cell. 2011 Dec 23;147(7):1484-97
pubmed: 22196726
Nucleic Acids Res. 2016 Sep 19;44(16):7911-21
pubmed: 27257067
Bioinformatics. 2012 Mar 15;28(6):884-5
pubmed: 22285829
Nucleic Acids Res. 2012 Jan;40(2):871-83
pubmed: 21933814
Genetics. 2005 Mar;169(3):1329-42
pubmed: 15654101
Nature. 2001 Oct 4;413(6855):538-42
pubmed: 11586364
Methods Enzymol. 2001;342:159-67
pubmed: 11586890
Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17988-93
pubmed: 19004762
Mol Cell. 2014 May 8;54(3):431-44
pubmed: 24703949
Mol Syst Biol. 2014 Jan 30;10:717
pubmed: 24489117
Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13962-7
pubmed: 16166263
Mol Syst Biol. 2011 Jan 4;7:458
pubmed: 21206491
Methods Mol Biol. 2018;1720:35-54
pubmed: 29236250
Nat Methods. 2013 Feb;10(2):119-21
pubmed: 23263691
Mol Cell Biol. 1997 Jan;17(1):287-95
pubmed: 8972209
Genome Biol. 2015 Dec 17;16:282
pubmed: 26679539
Mol Cell. 2009 Oct 9;36(1):99-109
pubmed: 19818713
Mol Biol Cell. 2004 Jul;15(7):3015-30
pubmed: 15090619
Eukaryot Cell. 2011 Dec;10(12):1679-93
pubmed: 21984708
RNA. 2004 Oct;10(10):1572-85
pubmed: 15337846