Reduced Anti-Histone Antibodies and Increased Risk of Rheumatoid Arthritis Associated with a Single Nucleotide Polymorphism in PADI4 in North Americans.

Alleles Arthritis, Rheumatoid / diagnosis Autoantibodies / blood Autoantigens / immunology Disease Susceptibility Extracellular Traps / immunology Genotype Histones / immunology Humans Immunoglobulin G / blood Neutrophils / immunology Polymorphism, Single Nucleotide Protein-Arginine Deiminase Type 4 / genetics
autoantibody neutrophil extracellular trap peptidylarginine deiminase 4 rheumatoid arthritis single nucleotide polymorphism

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
25 Jun 2019
Historique:
received: 20 05 2019
revised: 20 06 2019
accepted: 21 06 2019
entrez: 28 6 2019
pubmed: 28 6 2019
medline: 18 12 2019
Statut: epublish

Résumé

Autoantibodies against citrullinated proteins are a hallmark of rheumatoid arthritis, a destructive inflammatory arthritis. Peptidylarginine deiminase 4 (PAD4) has been hypothesized to contribute to rheumatoid arthritis by citrullinating histones to induce neutrophil extracellular traps (NETs), which display citrullinated proteins that are targeted by autoantibodies to drive inflammation and arthritis. Consistent with this theory, PAD4-deficient mice have reduced NETs, autoantibodies, and arthritis. However, PAD4's role in human rheumatoid arthritis is less clear. Here, we determine if single nucleotide polymorphism rs2240335 in

Identifiants

DOI: 10.3390/ijms20123093 PMID: 31242568 PMC: PMC6627847
pubmed: 31242568
pii: ijms20123093
doi: 10.3390/ijms20123093
pmc: PMC6627847
pii:
doi:

Substances chimiques

Autoantibodies 0
Autoantigens 0
Histones 0
Immunoglobulin G 0
PADI4 protein, human EC 3.5.3.15
Protein-Arginine Deiminase Type 4 EC 3.5.3.15

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Doris Duke Charitable Foundation
ID : 2015099
Pays : United States
Organisme : NIH HHS
ID : T32HL07899
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007899
Pays : United States
Organisme : NIAMS NIH HHS
ID : K08 AR065500
Pays : United States
Organisme : NIH HHS
ID : K08AR065500
Pays : United States
Organisme : University of Wisconsin School of Medicine and Public Health from the Wisconsin Partnership Program
ID : N/A

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Auteurs

Aisha M Mergaert (AM)

Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA. mergaert@wisc.edu.
Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA. mergaert@wisc.edu.

Mandar Bawadekar (M)

Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA. mandar.bawadekar@gmail.com.
ORCID: 0000-0002-4113-8669

Thai Q Nguyen (TQ)

Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA. nguyen45@wisc.edu.

Laura Massarenti (L)

Institute for Inflammation Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark. laura.massarenti@regionh.dk.
ORCID: 0000-0001-5647-4617

Caitlyn L Holmes (CL)

Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA. cherndon@medicine.wisc.edu.
Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA. cherndon@medicine.wisc.edu.

Ryan Rebernick (R)

Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA. reberya@gmail.com.

Steven J Schrodi (SJ)

Center for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, WI 54449, USA. schrodi.steven@marshfieldresearch.org.
ORCID: 0000-0003-2304-8528

Miriam A Shelef (MA)

Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA. mshelef@medicine.wisc.edu.
William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA. mshelef@medicine.wisc.edu.
ORCID: 0000-0002-8842-0303

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Allèles › Reduced Anti-Histone Antibodies and Increased...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Polyarthrite rhumatoïde › Reduced Anti-Histone Antibodies and Increased...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › Reduced Anti-Histone Antibodies and Increased...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Autoantigènes › Reduced Anti-Histone Antibodies and Increased...
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Prédisposition aux maladies › Reduced Anti-Histone Antibodies and Increased...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Pièges extracellulaires › Reduced Anti-Histone Antibodies and Increased...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Reduced Anti-Histone Antibodies and Increased...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › Reduced Anti-Histone Antibodies and Increased...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Reduced Anti-Histone Antibodies and Increased...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline G › Reduced Anti-Histone Antibodies and Increased...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Granulocytes neutrophiles › Reduced Anti-Histone Antibodies and Increased...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Reduced Anti-Histone Antibodies and Increased...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Protein-arginine deiminases › Protein-arginine deiminase Type 4 › Reduced Anti-Histone Antibodies and Increased...