Effects of Estrogens on Platelets and Megakaryocytes.
estrogens
megakaryocytes
platelets
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 Jun 2019
25 Jun 2019
Historique:
received:
23
05
2019
revised:
14
06
2019
accepted:
19
06
2019
entrez:
28
6
2019
pubmed:
28
6
2019
medline:
18
12
2019
Statut:
epublish
Résumé
In women, oral menopausal hormonal therapy (MHT) is associated with adverse effects including an increased incidence of thromboembolic events, classically attributed to an increase in several liver-derived coagulation factors due to hepatic first pass. While platelets are central players in thrombus constitution, their implication in women treated with estrogens remains incompletely characterized. Platelets and their medullar progenitors, megakaryocytes, express estrogen receptors (ER) that may explain, at least in part, a sensitivity to hormonal changes. The purpose of this review is to summarize our current knowledge of estrogen actions on platelets and megakaryocytes in mice following in vivo administration and in women using MHT.
Identifiants
pubmed: 31242705
pii: ijms20123111
doi: 10.3390/ijms20123111
pmc: PMC6627332
pii:
doi:
Substances chimiques
Estrogens
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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