Fluoxetine Induces Morphological Rearrangements of Serotonergic Fibers in the Hippocampus.
Animals
Antidepressive Agents
/ pharmacology
Behavior, Animal
/ drug effects
Cell Shape
/ drug effects
Fluoxetine
/ pharmacology
Hippocampus
/ drug effects
Male
Mice
Mice, Transgenic
Nerve Fibers
/ drug effects
Neurons
/ drug effects
Serotonergic Neurons
/ drug effects
Selective Serotonin Reuptake Inhibitors
/ pharmacology
Swimming
fluoxetine
hippocampus
plasticity
serotonergic fibers
serotonin
Journal
ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337
Informations de publication
Date de publication:
17 07 2019
17 07 2019
Historique:
pubmed:
28
6
2019
medline:
12
6
2020
entrez:
28
6
2019
Statut:
ppublish
Résumé
Serotonin (5-HT)-releasing fibers show substantial structural plasticity in response to genetically induced changes in 5-HT content. However, whether 5-HT fibers appear malleable also following clinically relevant variations in 5-HT levels that may occur throughout an individual's life has not been investigated. Here, using confocal imaging and 3D modeling analysis in
Identifiants
pubmed: 31243951
doi: 10.1021/acschemneuro.8b00655
doi:
Substances chimiques
Antidepressive Agents
0
Serotonin Uptake Inhibitors
0
Fluoxetine
01K63SUP8D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM