The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy.
Animals
Antigens, Neoplasm
/ genetics
Antineoplastic Agents, Immunological
/ pharmacology
Apoptosis
Carcinoma, Pancreatic Ductal
/ drug therapy
Cell Line, Tumor
Cell Movement
Cell Proliferation
Dual Specificity Phosphatase 6
/ genetics
Female
Gene Expression Regulation, Neoplastic
Genes, ras
Humans
Integrases
/ genetics
Integrins
/ antagonists & inhibitors
Italy
Mice, Nude
Mice, Transgenic
Neoplasm Invasiveness
Pancreatic Neoplasms
/ drug therapy
Signal Transduction
Tumor Burden
Tumor Microenvironment
United Kingdom
Xenograft Model Antitumor Assays
264RAD
PDAC
cancer
integrin
mouse model
pancreas
transgenic
αvβ6
Journal
The Journal of pathology
ISSN: 1096-9896
Titre abrégé: J Pathol
Pays: England
ID NLM: 0204634
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
17
01
2019
revised:
22
05
2019
accepted:
21
06
2019
pubmed:
2
7
2019
medline:
14
4
2020
entrez:
2
7
2019
Statut:
ppublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) has a 5-year survival rate of less than 4% and desperately needs novel effective therapeutics. Integrin αvβ6 has been linked with poor prognosis in cancer but its potential as a target in PDAC remains unclear. We report that transcriptional expression analysis revealed that high levels of β6 mRNA correlated strongly with significantly poorer survival (n = 491 cases, p = 3.17 × 10
Identifiants
pubmed: 31259422
doi: 10.1002/path.5320
pmc: PMC6852434
doi:
Substances chimiques
Antigens, Neoplasm
0
Antineoplastic Agents, Immunological
0
Integrins
0
integrin alphavbeta6
0
Cre recombinase
EC 2.7.7.-
Integrases
EC 2.7.7.-
Dual Specificity Phosphatase 6
EC 3.1.3.48
Dusp6 protein, mouse
EC 3.1.3.48
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
332-342Subventions
Organisme : CRUK Core Facilities at Barts Cancer Institute, London
ID : C16420/A18066
Pays : International
Organisme : Pancreatic Cancer UK
ID : FLF2015_04_GLASGOW
Pays : United Kingdom
Organisme : Pancreatic Cancer UK
ID : RIF2015_A06_JAMIESON
Pays : United Kingdom
Organisme : Cancer Research UK
ID : 11650
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Training Fellowship
Pays : International
Organisme : Medical Research Council
ID : G0800825
Pays : United Kingdom
Informations de copyright
© 2019 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
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