Influence of
ABO Blood-Group System
/ genetics
Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Factor VIII
/ genetics
Female
Humans
Male
Middle Aged
Phenotype
Platelet Aggregation
/ genetics
Platelet Function Tests
Polymorphism, Single Nucleotide
Thrombophilia
/ genetics
von Willebrand Factor
/ genetics
ABO blood-group system
factor VIII
platelet function test
platelet reactivity
von Willebrand factor
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 Jun 2019
30 Jun 2019
Historique:
received:
03
06
2019
revised:
24
06
2019
accepted:
27
06
2019
entrez:
3
7
2019
pubmed:
3
7
2019
medline:
18
12
2019
Statut:
epublish
Résumé
(1) Background: In a previous study, we found that two phenotypes related to platelet reactivity, measured with the PFA-100 system, were highly heritable. The aim of the present study was to identify genetic determinants that influence the variability of these phenotypes: closure time of collagen-ADP (Col-ADP) and of collagen-epinephrine (Col-Epi). (2) Methods: As part of the GAIT-2 (Genetic Analysis of Idiopathic Thrombophilia (2) Project, 935 individuals from 35 large Spanish families were studied. A genome-wide association study (GWAS) with ≈ 10 M single nucleotide polymorphisms (SNPs) was carried out with Col-ADP and Col-Epi phenotypes. (3) Results: The study yielded significant genetic signals that mapped to the
Identifiants
pubmed: 31262040
pii: ijms20133221
doi: 10.3390/ijms20133221
pmc: PMC6651679
pii:
doi:
Substances chimiques
ABO Blood-Group System
0
von Willebrand Factor
0
Factor VIII
9001-27-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerio de Educación y Ciencia
ID : SAF 2005-04738
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