Safety, Pharmacokinetics, and Food Effect of Tebipenem Pivoxil Hydrobromide after Single and Multiple Ascending Oral Doses in Healthy Adult Subjects.
carbapenem
oral
pharmacokinetics
tebipenem
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
22
03
2019
accepted:
16
05
2019
pubmed:
3
7
2019
medline:
18
7
2020
entrez:
3
7
2019
Statut:
epublish
Résumé
Tebipenem pivoxil hydrobromide (TBPM-PI-HBr, formerly SPR994) is an orally available prodrug of tebipenem, a carbapenem with activity versus multidrug-resistant (MDR) Gram-negative pathogens, including quinolone-resistant and extended-spectrum-β-lactamase-producing
Identifiants
pubmed: 31262768
pii: AAC.00618-19
doi: 10.1128/AAC.00618-19
pmc: PMC6709501
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Carbapenems
0
Prodrugs
0
tebipenem
Q2TWQ1I31U
Banques de données
ClinicalTrials.gov
['NCT03395249']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 Eckburg et al.
Références
J Infect Dis. 2017 Feb 15;215(suppl_1):S28-S36
pubmed: 28375512
Antimicrob Agents Chemother. 2019 Mar 27;63(4):
pubmed: 30718255
Drug Resist Updat. 2016 Nov;29:30-46
pubmed: 27912842
Antimicrob Agents Chemother. 2019 May 24;63(6):
pubmed: 30936096
Clin Infect Dis. 2018 Nov 28;67(12):1803-1814
pubmed: 30052813