Mitochondrial numbers increase during glucose deprivation in the slime mold Physarum polycephalum.
AMPK
Glucose deprivation
Mitochondria
Physarum polycephalum
Stereology
Journal
Protoplasma
ISSN: 1615-6102
Titre abrégé: Protoplasma
Pays: Austria
ID NLM: 9806853
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
20
04
2019
accepted:
18
06
2019
pubmed:
4
7
2019
medline:
25
3
2020
entrez:
4
7
2019
Statut:
ppublish
Résumé
Glucose deprivation in the slime mold Physarum polycephalum leads to a specific morphotype, a highly motile mesoplasmodium. We investigated the ultrastructure of both mesoplasmodia and non-starved plasmodia and found significantly increased numbers of mitochondria in glucose-deprived mesoplasmodia. The volume of individual mitochondria was the same in both growth forms. We conjecture that the number of mitochondria correlates with the metabolic state of the cell: When glucose is absent, the slime mold is forced to switch to different metabolic pathways, which occur inside mitochondria. Furthermore, a catabolic cue (such as AMP-activated protein kinase (AMPK)) could stimulate mitochondrial biogenesis.
Identifiants
pubmed: 31267225
doi: 10.1007/s00709-019-01410-1
pii: 10.1007/s00709-019-01410-1
pmc: PMC6820597
doi:
Substances chimiques
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1647-1655Références
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