The C-type Lectin Receptor CLEC12A Recognizes Plasmodial Hemozoin and Contributes to Cerebral Malaria Development.

Animals CD8-Positive T-Lymphocytes / immunology Cross-Priming Dendritic Cells / immunology Disease Models, Animal Granzymes / metabolism Hemeproteins / immunology Immunity, Innate Lectins, C-Type / genetics Malaria, Cerebral / immunology Mice Mice, Inbred C57BL Plasmodium berghei / pathogenicity Receptors, Mitogen / genetics T-Lymphocytes
C-type lectin receptor MICL/CLEC12A Plasmodium berghei cerebral malaria hemozoin

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
02 07 2019
Historique:
received: 05 09 2017
revised: 15 03 2019
accepted: 04 06 2019
entrez: 4 7 2019
pubmed: 4 7 2019
medline: 28 8 2020
Statut: ppublish

Résumé

Malaria represents a major cause of death from infectious disease. Hemozoin is a Plasmodium-derived product that contributes to progression of cerebral malaria. However, there is a gap of knowledge regarding how hemozoin is recognized by innate immunity. Myeloid C-type lectin receptors (CLRs) encompass a family of carbohydrate-binding receptors that act as pattern recognition receptors in innate immunity. In the present study, we identify the CLR CLEC12A as a receptor for hemozoin. Dendritic cell-T cell co-culture assays indicate that the CLEC12A/hemozoin interaction enhances CD8

Identifiants

DOI: 10.1016/j.celrep.2019.06.015 PMID: 31269448 PMC: PMC6616648
pubmed: 31269448
pii: S2211-1247(19)30781-8
doi: 10.1016/j.celrep.2019.06.015
pmc: PMC6616648
pii:
doi:

Substances chimiques

CLEC12A protein, human 0
CLEC12A protein, mouse 0
Hemeproteins 0
Lectins, C-Type 0
Receptors, Mitogen 0
hemozoin 39404-00-7
Granzymes EC 3.4.21.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

30-38.e5

Informations de copyright

Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.

Références

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Auteurs

Marie-Kristin Raulf (MK)

Immunology Unit and Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, 30559 Hannover, Lower Saxony, Germany; Institute for Parasitology, Centre for Infection Medicine, University of Veterinary Medicine Hannover, 30559 Hannover, Lower Saxony, Germany.

Timo Johannssen (T)

Immunology Unit and Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, 30559 Hannover, Lower Saxony, Germany; Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Brandenburg, Germany; Department of Biology, Chemistry and Pharmacy, Institute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany.

Svea Matthiesen (S)

Immunology Unit and Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, 30559 Hannover, Lower Saxony, Germany.

Konstantin Neumann (K)

Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Bavaria, Germany; Institute of Clinical Chemistry, Hannover Medical School, 30625 Hannover, Lower Saxony, Germany.

Severin Hachenberg (S)

Immunology Unit and Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, 30559 Hannover, Lower Saxony, Germany.

Sabine Mayer-Lambertz (S)

Immunology Unit and Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, 30559 Hannover, Lower Saxony, Germany.

Fridolin Steinbeis (F)

Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Brandenburg, Germany; Charité-Universitätsmedizin Berlin, Klinik mit Schwerpunkt Infektiologie und Pneumologie, 13353 Berlin, Berlin, Germany.

Jan Hegermann (J)

Research Core Unit Electron Microscopy, Hannover Medical School, 30625 Hannover, Lower Saxony, Germany.

Peter H Seeberger (PH)

Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Brandenburg, Germany; Department of Biology, Chemistry and Pharmacy, Institute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany.

Wolfgang Baumgärtner (W)

Department of Pathology, University of Veterinary Medicine Hannover, 30559 Hannover, Lower Saxony, Germany.

Christina Strube (C)

Institute for Parasitology, Centre for Infection Medicine, University of Veterinary Medicine Hannover, 30559 Hannover, Lower Saxony, Germany.

Jürgen Ruland (J)

Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Bavaria, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Baden-Württemberg, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Munich, Bavaria, Germany.

Bernd Lepenies (B)

Immunology Unit and Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, 30559 Hannover, Lower Saxony, Germany; Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Brandenburg, Germany; Department of Biology, Chemistry and Pharmacy, Institute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany. Electronic address: bernd.lepenies@tiho-hannover.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The C-type Lectin Receptor CLEC12A Recognizes...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › The C-type Lectin Receptor CLEC12A Recognizes...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Cross-priming › The C-type Lectin Receptor CLEC12A Recognizes...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › The C-type Lectin Receptor CLEC12A Recognizes...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › The C-type Lectin Receptor CLEC12A Recognizes...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Serine endopeptidases › Granzymes › The C-type Lectin Receptor CLEC12A Recognizes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › The C-type Lectin Receptor CLEC12A Recognizes...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › The C-type Lectin Receptor CLEC12A Recognizes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lectines › Lectines de type C › The C-type Lectin Receptor CLEC12A Recognizes...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Infections du système nerveux central › Infections parasitaires du système nerveux central › Protozooses du système nerveux central › Paludisme cérébral › The C-type Lectin Receptor CLEC12A Recognizes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The C-type Lectin Receptor CLEC12A Recognizes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › The C-type Lectin Receptor CLEC12A Recognizes...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Plasmodium berghei › The C-type Lectin Receptor CLEC12A Recognizes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteur mitogène › The C-type Lectin Receptor CLEC12A Recognizes...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › The C-type Lectin Receptor CLEC12A Recognizes...