Short-term evaluation of cardiac morphology, function, metabolism and structure following diagnosis of adult-onset growth hormone deficiency.
Absorptiometry, Photon
Adult
Body Composition
Case-Control Studies
Cross-Sectional Studies
Female
Growth Disorders
/ diagnosis
Heart
/ diagnostic imaging
Human Growth Hormone
/ deficiency
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Ventricular Dysfunction, Left
/ diagnostic imaging
Young Adult
Diastolic function
Gadolinium late-enhancement
High energy phosphates
Insulin like growth factor 1
Phosphorus 31 magnetic resonance spectroscopy
Journal
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
ISSN: 1532-2238
Titre abrégé: Growth Horm IGF Res
Pays: Scotland
ID NLM: 9814320
Informations de publication
Date de publication:
Historique:
received:
01
03
2019
revised:
03
06
2019
accepted:
24
06
2019
pubmed:
6
7
2019
medline:
7
1
2020
entrez:
6
7
2019
Statut:
ppublish
Résumé
The impact of growth hormone (GH) deficiency of the adult on cardiovascular function remains only partially elucidated. Purpose of this study was to test cardiac function in adult GH deficient patients using cardiac magnetic resonance (CMR). Cardiac magnetic resonance (CMR) techniques, including cardiac In GH deficient patients LV systolic function (EF%: 61 ± 1.7 vs 62.1 ± 0.8; p = .44) was not different in spite of a lower LV mass (83.2 ± 5.3 vs 145.3 ± 11.9 g; p = .001), a subclinical impairment of diastolic function (E/A peak ratio: 1.6 ± 0.2 vs 2.1 ± 0.2 p = .05), and a trend for lower PCr/ATP ratio (2.1 ± 0.8 vs 2.3 ± 0.1 p = .07). The RV showed reduced chamber size (end diastolic volume 123.8 ± 9 vs 147.9 ± 7.6 mL; p = .021) with preserved mass. No structural alterations of the LV and RV at late-enhancement were detected in these patients. GH deficient patients represent a unique model of reduced LV myocardial mass in which major structural and metabolic alterations are lacking. Mal-adaptive mechanisms developing in the long term in response to GH deficiency and more severely affecting the LV remain to be elucidated.
Identifiants
pubmed: 31276905
pii: S1096-6374(19)30028-0
doi: 10.1016/j.ghir.2019.06.003
pii:
doi:
Substances chimiques
Human Growth Hormone
12629-01-5
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
50-54Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.