Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome.

Action Potentials / genetics Animals Brain / metabolism Epilepsies, Myoclonic / genetics Interneurons / metabolism Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Mice, Transgenic NAV1.1 Voltage-Gated Sodium Channel / genetics Vasoactive Intestinal Peptide / genetics
Nav1.1 SCN1A electrophysiology epilepsy ion channels mouse neuroscience

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
08 07 2019
Historique:
received: 14 03 2019
accepted: 07 07 2019
pubmed: 10 7 2019
medline: 3 3 2020
entrez: 9 7 2019
Statut: epublish

Résumé

Dravet Syndrome (DS) is a severe neurodevelopmental disorder caused by pathogenic loss of function variants in the gene

Identifiants

DOI: 10.7554/eLife.46846 PMID: 31282864 PMC: PMC6629374
pubmed: 31282864
doi: 10.7554/eLife.46846
pii: 46846
pmc: PMC6629374
doi:
pii:

Substances chimiques

NAV1.1 Voltage-Gated Sodium Channel 0
Scn1a protein, mouse 0
Vasoactive Intestinal Peptide 37221-79-7

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NINDS NIH HHS
ID : F31 NS111803
Pays : United States
Organisme : NINDS NIH HHS
ID : K08 NS097633
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS110869
Pays : United States
Organisme : Burroughs Wellcome Fund
ID : Career Award for Medical Scientists
Pays : International

Informations de copyright

© 2019, Goff and Goldberg.

Déclaration de conflit d'intérêts

KG, EG No competing interests declared

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Auteurs

Kevin M Goff (KM)

Department of Neuroscience, The University of Pennsylvania Perelman School of Medicine, Philadelphia, United States.
The Medical Scientist Training Program, The University of Pennsylvania Perelman School of Medicine, Philadelphia, United States.
ORCID: 0000-0001-5862-0219

Ethan M Goldberg (EM)

Department of Neuroscience, The University of Pennsylvania Perelman School of Medicine, Philadelphia, United States.
Division of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, United States.
Department of Neurology, The University of Pennsylvania Perelman School of Medicine, Philadelphia, United States.
ORCID: 0000-0002-7404-735X

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Potentiels d'action › Vasoactive intestinal peptide-expressing...
questionsmedicales.fr › Eucaryotes › Animaux › Vasoactive intestinal peptide-expressing...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Vasoactive intestinal peptide-expressing...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Épilepsie › Syndromes épileptiques › Épilepsies myocloniques › Vasoactive intestinal peptide-expressing...
questionsmedicales.fr › Cellules › Neurones › Interneurones › Vasoactive intestinal peptide-expressing...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Souris de souche-129 › Vasoactive intestinal peptide-expressing...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Vasoactive intestinal peptide-expressing...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Vasoactive intestinal peptide-expressing...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Vasoactive intestinal peptide-expressing...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Canaux sodiques voltage-dépendants › Canal sodique voltage-dépendant NAV1.1 › Vasoactive intestinal peptide-expressing...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Peptide vasoactif intestinal › Vasoactive intestinal peptide-expressing...