Nerve ultrasound can identify treatment-responsive chronic neuropathies without electrodiagnostic features of demyelination.
Aged
Brachial Plexus
/ diagnostic imaging
Electrodiagnosis
Female
Humans
Immunoglobulins, Intravenous
/ therapeutic use
Immunologic Factors
/ therapeutic use
Male
Median Nerve
/ diagnostic imaging
Middle Aged
Neural Conduction
/ physiology
Organ Size
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
/ diagnostic imaging
Ultrasonography
EMG
chronic inflammatory demyelinating polyneuropathy
multifocal motor neuropathy
nerve enlargement
nerve ultrasound
Journal
Muscle & nerve
ISSN: 1097-4598
Titre abrégé: Muscle Nerve
Pays: United States
ID NLM: 7803146
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
14
12
2018
revised:
01
07
2019
accepted:
05
07
2019
pubmed:
12
7
2019
medline:
15
1
2020
entrez:
12
7
2019
Statut:
ppublish
Résumé
We present a case series of six treatment-naive patients with clinical phenotypes compatible with chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy without electrodiagnostic features of demyelination but with abnormal peripheral ultrasound findings who responded to treatment. All six patients underwent a complete set of ancillary investigations, including extensive nerve conduction studies. We also performed standardized nerve ultrasound of median nerves and brachial plexus as part of a larger effort to evaluate diagnostic value of sonography. Nerve conduction studies did not show conduction block or other signs of demyelination in any of the six patients. Sonographic nerve enlargement was present in all patients and was most prominent in proximal segments of the median nerve and brachial plexus. Treatment with intravenous immunoglobulin resulted in objective clinical improvement. Our study provides evidence that nerve ultrasound represents a useful complementary diagnostic tool for the identification of treatment-responsive inflammatory neuropathies.
Identifiants
pubmed: 31294858
doi: 10.1002/mus.26629
pmc: PMC6771613
doi:
Substances chimiques
Immunoglobulins, Intravenous
0
Immunologic Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
415-419Informations de copyright
© 2019 The Authors. Muscle & Nerve published by Wiley Periodicals, Inc.
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